GSTDTAP  > 资源环境科学
DOI10.1289/EHP296
Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009
Demoury, Claire1; Marquant, Fabienne1; Ielsch, Geraldine2; Goujon, Stephanie1,3; Debayle, Christophe4; Faure, Laure1,3; Coste, Astrid1; Laurent, Olivier5; Guillevic, Jerome2; Laurier, Dominique5; Hemon, Denis1; Clavel, Jacqueline1,3
2017-04-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:4
文章类型Article
语种英语
国家France
英文摘要

BACKGROUND: Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined.


METHODS: AL cases diagnosed over 1990-2009 (9,056 cases) were identified and their municipality of residence at diagnosis collected by the National Registry of Childhood Cancers. The Geocap study, which included the 2,763 cases in 2002-2007 and 30,000 population controls, was used for complementary analyses. NBR exposures were modeled on a fine scale (36,326 municipalities) based on measurement campaigns and geological data. The power to detect an association between AL and dose to the red bone marrow (RBM) fitting UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) predictions was 92%, 45% and 99% for exposure to natural gamma radiation, radon and total radiation, respectively.


RESULTS: AL risk, irrespective of subtype and age group, was not associated with the exposure of municipalities to radon or gamma radiation in terms of yearly exposure at age reached, cumulative exposure or RBM dose. There was no confounding effect of census-based socio-demographic indicators, or environmental factors (road traffic, high voltage power lines, vicinity of nuclear plants) related to AL in the Geocap study.


CONCLUSIONS: Our findings do not support the hypothesis that residential exposure to NBR increases the risk of AL, despite the large size of the study, fine scale exposure estimates and wide range of exposures over France. However, our results at the time of diagnosis do not rule out a slight association with gamma radiation at the time of birth, which would be more in line with the recent findings in the UK and Switzerland.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000397904400035
WOS关键词ATOMIC-BOMB SURVIVORS ; RADON EXPOSURE ; IONIZING-RADIATION ; TERRESTRIAL GAMMA ; MULTIPLE-MYELOMA ; DOMESTIC RADON ; GREAT-BRITAIN ; INDOOR RADON ; CANCER ; LYMPHOMA
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/22951
专题资源环境科学
作者单位1.Univ Sorbonne Paris Cite, Univ Paris Descartes, INSERM, CRESS EPICEA Epidemiol Canc Enfant & Adolescent, Paris, France;
2.Bur Etud & Expertise Radon & Modelisat PRP DGE SE, IRSN, Fontenay Aux Roses, France;
3.French Natl Registry Childhood Hematol Malignanci, Villejuif, France;
4.IRSN, Lab Surveillance Atmospher & Alerte PRP ENV SESUR, Le Vesinet, France;
5.IRSN, Lab Epidemiol Rayonnements Ionisants PRP HOM SRBE, Fontenay Aux Roses, France
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GB/T 7714
Demoury, Claire,Marquant, Fabienne,Ielsch, Geraldine,et al. Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4).
APA Demoury, Claire.,Marquant, Fabienne.,Ielsch, Geraldine.,Goujon, Stephanie.,Debayle, Christophe.,...&Clavel, Jacqueline.(2017).Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4).
MLA Demoury, Claire,et al."Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017).
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