Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP500 |
Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study | |
Wang, Xu1; Ouyang, Fengxiu1; Feng, Liping2; Wang, Xia1; Liu, Zhiwei3; Zhang, Jun1 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | BACKGROUND:.Triclosan (TCS) is a synthetic antibacterial chemical widely used in personal care products. TCS exposure has been associated with decreased thyroid hormone levels in animals, but human studies are scarce and controversial. OBJECTIVE: We evaluated the association between maternal TCS exposure and thyroid hormone, levels of mothers and newborns. METHODS: TCS was measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) in urine samples collected during gestational weeks 38.8 +/- 1.1 from 398 pregnant women in a prospective birth cohort enrolled in 2012-2013 in Shanghai, China. Maternal serum levels of free thyroxine (FT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were obtained from medical records. Cord blood levels of free triiodothyronine (FT3), FT4, TSH, and TPOAb were measured. Multiple linear and logistic regression models were used to examine the relationship between maternal urinary TCS and thyroid hormone levels. RESULTS: TCS was detectable (>= 0.1 ng/mL) in 98.24% of maternal urine samples with tertile of urinary TCS levels: low (<0.1-2.75 mu g/g.Cr), medium (2.75-9.78 mu g/g.Cr, and high (9.78-427.38 mu g/g.Cr. With adjustment for potential confounders, cord blood log(FT3)pmol/L concentration was 0.11 lower in newborns of mothers with medium and high urinary TCS levels compared with those with low levels. At third trimester, the high TCS concentration was associated with 0.03 [95% confidence interval (CI) - 0.08, -0.02] lower maternal serum log(FLOpmoltE whereas the medium TCS concentration was associated with 0.15 (95% CI: -0.28, -0.03) lower serum log(TSH)MIU/L. with adjustment for covariates. CONCLUSIONS: Our results suggest significant inverse associations between maternal urinary TCS and cord blood FT3 as well as maternal blood FT4 concentrations at third trimester. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413788400026 |
WOS关键词 | BISPHENOL-A ; PREGNANT-WOMEN ; NEUROPSYCHOLOGICAL DEVELOPMENT ; IN-VIVO ; EXPOSURE ; THYROXINE ; HYPOTHYROIDISM ; TOOTHPASTE ; CHINA |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22968 |
专题 | 资源环境科学 |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE Shanghai Key Lab Childrens Environm Hlth, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China; 2.Duke Univ, Sch Med, Dept Obstet & Gynecol, Durham, NC USA; 3.Shanghai Jiao Tong Univ, Sch Med, Int Peace Maternal & Child Hlth Hosp, Dept Neonatol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xu,Ouyang, Fengxiu,Feng, Liping,et al. Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Wang, Xu,Ouyang, Fengxiu,Feng, Liping,Wang, Xia,Liu, Zhiwei,&Zhang, Jun.(2017).Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Wang, Xu,et al."Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
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