The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study

doi:10.1289/EHP142

GSTDTAP > 资源环境科学

DOI	10.1289/EHP142
	The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study
	Goudarzi, Houman 1; Araki, Atsuko 1; Itoh, Sachiko 1; Sasaki, Seiko 2; Miyashita, Chihiro 1; Mitsui, Takahiko 3; Nakazawa, Hiroyuki 4; Nonomura, Katsuya 5,6; Kishi, Reiko 1
	2017
发表期刊	ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN	0091-6765
EISSN	1552-9924
出版年	2017
卷号	125 期号:1
文章类型	Article
语种	英语
国家	Japan
英文摘要	BACKGROUND: Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and steroid hormones such as glucocorticoids and androgenic hormones mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on the homeostasis of these steroid hormones are not well understood in humans. OBJECTIVES: We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. METHODS: We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n = 514). In total, 185 mother-infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones [dehydroepiandrosterone (DHEA) and androstenedione] were also measured in the same way. RESULTS: We found a dose-response relationship of prenatal PFOS, but not PFOA, exposure with glucocorticoid levels after adjusting for potential confounders. Cortisol and cortisone concentrations were -23.98-ng/mL (95% CI: -0.47.12, -11.99; p for trend = 0.006) and -63.21-ng/mL (95% CI: -132.56, -26.72; p for trend < 0.001) lower, respectively, in infants with prenatal PFOS exposure in the fourth quartile compared with those in the first quartile. The highest quartile of prenatal PFOS exposure was positively associated with a 1.33-ng/mL higher DHEA level compared with the lowest quartile (95% CI: 0.17, 1.82; p for trend = 0.017), whereas PFOA showed a negative association with DHEA levels (quartile 4 vs. quartile 1: -1.23 ng/mL, 95% CI: -1.72, -0.25; p for trend = 0.004). We observed no significant association between PFCs and androstenedione levels. CONCLUSIONS: Our results indicate that prenatal exposure to PFCs is significantly associated with glucocorticoid and DHEA levels in cord blood.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000392195000015
WOS关键词	TANDEM MASS-SPECTROMETRY ; PERFLUOROOCTANE SULFONATE ; PERFLUOROALKYL SUBSTANCES ; LIQUID-CHROMATOGRAPHY ; CHILDRENS HEALTH ; SYNTHETIC GLUCOCORTICOIDS ; COHORT PROFILE ; BIRTH-WEIGHT ; FETAL-GROWTH ; IN-UTERO
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/23096
专题	资源环境科学
作者单位	1.Hokkaido Univ, Ctr Environm & Hlth Sci, Sapporo, Hokkaido, Japan; 2.Hokkaido Univ, Dept Publ Hlth, Grad Sch Med, Sapporo, Hokkaido, Japan; 3.Hokkaido Univ Hosp, Dept Urol, Sapporo, Hokkaido, Japan; 4.Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Tokyo, Japan; 5.Hokkaido Univ, Grad Sch Med, Dept Renal & Genitourinary Surg, Sapporo, Hokkaido, Japan; 6.Kushiro Rosai Hosp, Kushiro, Hokkaido, Japan
推荐引用方式 GB/T 7714	Goudarzi, Houman,Araki, Atsuko,Itoh, Sachiko,et al. The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(1).
APA	Goudarzi, Houman.,Araki, Atsuko.,Itoh, Sachiko.,Sasaki, Seiko.,Miyashita, Chihiro.,...&Kishi, Reiko.(2017).The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(1).
MLA	Goudarzi, Houman,et al."The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.1(2017).