GSTDTAP  > 资源环境科学
DOI10.1289/EHP408
Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data
Sand, Salomon1,2; Parham, Fred3; Portier, Christopher J.4; Tice, Raymond R.3; Krewski, Daniel2,5
2017-04-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:4
文章类型Article
语种英语
国家Sweden; Canada; USA; Netherlands
英文摘要

BACKGROUND: The National Research Council's vision for toxicity testing in the 21st century anticipates that points of departure (PODs) for establishing human exposure guidelines in future risk assessments will increasingly be based on invitro high-throughput screening (HTS) data. Objectives: The aim of this study was to compare different PODs for HTS data. Specifically, benchmark doses (BMDs) were compared to the signal-to-noise crossover dose (SNCD), which has been suggested as the lowest dose applicable as a POD.


METHODS: Hill models were fit to >10,000 invitro concentration-response curves, obtained for >1,400 chemicals tested as part of the U.S. Tox21 PhaseI effort. BMDs and lower confidence limits on the BMDs (BMDLs) corresponding to extra effects (i.e., changes in response relative to the maximum response) of 5%, 10%, 20%, 30%, and 40% were estimated for >8,000 curves, along with BMDs and BMDLs corresponding to additional effects (i.e., absolute changes in response) of 5%, 10%, 15%, 20%, and 25%. The SNCD, defined as the dose where the ratio between the additional effect and the difference between the upper and lower bounds of the two-sided 90% confidence interval on absolute effect was 1, 0.67, and 0.5, respectively, was also calculated and compared with the BMDLs.


RESULTS: The BMDL40, BMDL25, and BMDL18, defined in terms of extra effect, corresponded to the SNCD1.0, SNCD0.67, and SNCD0.5, respectively, at the median. Similarly, the BMDL25, BMDL17, and BMDL13, defined in terms of additional effect, corresponded to the SNCD1.0, SNCD0.67, and SNCD0.5, respectively, at the median.


CONCLUSIONS: The SNCD may serve as a reference level that guides the determination of standardized BMDs for risk assessment based on HTS concentration-response data. The SNCD may also have application as a POD for low-dose extrapolation.


领域资源环境
收录类别SCI-E ; SSCI
WOS记录号WOS:000397904400024
WOS关键词BENCHMARK DOSE CONCEPT ; OF-DEPARTURE ; TOXICITY ; SCIENCE ; FRAMEWORK ; EXPOSURE
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/23272
专题资源环境科学
作者单位1.Natl Food Agcy, Dept Risk Benefit Assessment, Uppsala, Sweden;
2.Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada;
3.NIEHS, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA;
4.Maastricht Univ, Dept Toxicogen, Maastricht, Netherlands;
5.Risk Sci Int, Ottawa, ON, Canada
推荐引用方式
GB/T 7714
Sand, Salomon,Parham, Fred,Portier, Christopher J.,et al. Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4).
APA Sand, Salomon,Parham, Fred,Portier, Christopher J.,Tice, Raymond R.,&Krewski, Daniel.(2017).Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4).
MLA Sand, Salomon,et al."Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sand, Salomon]的文章
[Parham, Fred]的文章
[Portier, Christopher J.]的文章
百度学术
百度学术中相似的文章
[Sand, Salomon]的文章
[Parham, Fred]的文章
[Portier, Christopher J.]的文章
必应学术
必应学术中相似的文章
[Sand, Salomon]的文章
[Parham, Fred]的文章
[Portier, Christopher J.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。