Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1246 |
Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study | |
Wu, Shaowei1; Hivert, Marie-France2,3; Cardenas, Andres2,3; Zhong, Jia4; Rifas-Shiman, Sheryl L.2,3; Agha, Golareh4; Colicino, Elena4; Just, Allan C.5; Amarasiriwardena, Chitra5; Lin, Xihong6; Litonjua, Augusto A.7; DeMeo, Dawn L.7; Gillman, Matthew W.8; Wright, Robert O.; Oken, Emily2,3; Baccarelli, Andrea A.4 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | BACKGROUND: Early-life exposure to lead is associated with deficits in neurodevelopment and with hematopoietic system toxicity. DNA methylation may be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposure are lacking. OBJECTIVES: We investigated the association between prenatal maternal lead exposure and epigenome-wide DNA methylation in umbilical cor nucleated cells in Project Viva, a prospective U.S.-based prebirth cohort with relatively low levels of lead exposure. METHODS: Among 268 mother infant pairs, we measured lead concentrations in red blood cells (RBC) from prenatal maternal blood samples, and using HumanMethylation450 Bead Chips, we measured genome-wide methylation levels at 482,397 CpG loci in umbilical cord blood and retained 394,460 loci after quality control. After adjustment for batch effects, cell types, and covariates, we used robust linear regression models to examine associations of prenatal lead exposure with DNA methylation in cord blood at epigenome-wide significance level [false discovery rate (FDR) <00.5]. RESULTS: The mean [standard deviation(SD)] maternal RBC lead level was 1.22 (0.63) mu g/dL. CpG cg10773601 showed an epigenome-wide significant negative association with prenatal lead exposure (-1.4% per doubling increase in lead exposure; p =2.3 x 10(-7)) and was annotated to C-Type Lectin Domain Family 11, Member A (CLEC1 1A), which functions as a growth factor for primitive hematopoietic progenitor cells. In sex-specific analyses, we identified more CpGs with FDR <0.05 among female infants (n=38) than among male infants (n = 2). One CpG (cg24637308), which showed a strong negative association with prenatal lead exposure among female infants (-4.3% per doubling increase in lead exposure; p= 1.1 x 10(-06)), was annotated to Dynein Heavy Chain Domain 1 gene (DNHD1) which is highly expressed in human brain. Interestingly, there were strong correlations between blood and brain methylation for CpG (cg24637308) based on another independent set of samples with a high proportion of female participants. CONCLUSION: Prenatal low-level lead exposure was associated with newborn DNA methylation, particularly in female infants. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600029 |
WOS关键词 | MATERNAL SMOKING ; PB EXPOSURE ; STEM-CELLS ; EXPRESSION ; PREGNANCY ; BIRTH ; HIPPOCAMPUS ; MICROARRAY ; PARAMETERS ; CHILDREN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23331 |
专题 | 资源环境科学 |
作者单位 | 1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, 38 Xueyuan Rd, Beijing, Peoples R China; 2.Harvard Med Sch, Dept Populat Med, Div Chron Dis Res Lifecourse, Boston, MA USA; 3.Harvard Pilgrim Hlth Care Inst, Boston, MA USA; 4.Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, 722 West 168th St,ARB 11th Floor 1105E, New York, NY 10032 USA; 5.Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; 7.Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA; 8.NIH, Environm Influences Child Hlth Outcomes ECHO Off, US Dept HHS, Rockville, MD USA |
推荐引用方式 GB/T 7714 | Wu, Shaowei,Hivert, Marie-France,Cardenas, Andres,et al. Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Wu, Shaowei.,Hivert, Marie-France.,Cardenas, Andres.,Zhong, Jia.,Rifas-Shiman, Sheryl L..,...&Baccarelli, Andrea A..(2017).Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Wu, Shaowei,et al."Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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