Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP152 |
Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment | |
Berg, Vivian1,2,3; Nost, Therese Haugdahl2,3; Pettersen, Rolf Dagfinn4; Hansen, Solrunn3; Veyhe, Anna-Sofia3; Jorde, Rolf5; Odland, Jon Oyvind3,6; Sandanger, Torkjel Manning2,3 | |
2017 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | Norway; South Africa |
英文摘要 | BACKGROUND: Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis. OBJECTIVES: We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Mother-and-Child Contaminant Cohort Study (MISA). METHODS: Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA). RESULTS: Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T-3, T-4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T-3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile. CONCLUSION: The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392195000017 |
WOS关键词 | ENDOCRINE-DISRUPTING CHEMICALS ; CHILD CONTAMINANT COHORT ; PERFLUOROALKYL SUBSTANCES ; PREGNANT-WOMEN ; POLYFLUOROALKYL SUBSTANCES ; POLYCHLORINATED-BIPHENYLS ; STIMULATING HORMONE ; EXPOSURE ; SERUM ; ACIDS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23336 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Hosp North Norway, Diagnost Clin, Tromso, Norway; 2.NILU Norwegian Inst Air Res, Fram Ctr, NO-9296 Tromso, Norway; 3.UIT Arctic Univ Norway, Dept Community Med, Tromso, Norway; 4.Oslo Univ Hosp, Women & Childrens Div, Norwegian Natl Unit Newborn Screening, Oslo, Norway; 5.UIT Arctic Univ Norway, Inst Clin Med, Tromso, Norway; 6.Univ Pretoria, Dept Publ Hlth, Pretoria, South Africa |
推荐引用方式 GB/T 7714 | Berg, Vivian,Nost, Therese Haugdahl,Pettersen, Rolf Dagfinn,et al. Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(1). |
APA | Berg, Vivian.,Nost, Therese Haugdahl.,Pettersen, Rolf Dagfinn.,Hansen, Solrunn.,Veyhe, Anna-Sofia.,...&Sandanger, Torkjel Manning.(2017).Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment.ENVIRONMENTAL HEALTH PERSPECTIVES,125(1). |
MLA | Berg, Vivian,et al."Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment".ENVIRONMENTAL HEALTH PERSPECTIVES 125.1(2017). |
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