Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1250 |
Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS) | |
Shaffer, Rachel M.1,2; Smith, Marissa N.1,2; Faustman, Elaine M.1,2 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Editorial Material |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Exposome-related efforts aim to document the totality of human exposures across the lifecourse. This field has advanced rapidly in recent years but lacks practical application to risk assessment, particularly for children's health. OBJECTIVES: Our objective was to apply the exposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapshots (LEnS). Case studies are presented to illustrate the value of the framework. DISCUSSION: The LEnS framework encourages organization of exposome studies based on windows of susceptibility for particular target organ systems. Such analyses will provide information regarding cumulative impacts during specific critical periods of the life course. A logical extension of this framework is that regulatory standards should analyze exposure information by target organ, rather than for a single chemical only or multiple chemicals grouped solely by mechanism of action. CONCLUSIONS: The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children's health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600003 |
WOS关键词 | NERVOUS-SYSTEM ; CONCEPTUAL-FRAMEWORK ; CHEMICALS ; VULNERABILITY ; CONSEQUENCES ; METABOLOMICS ; BIOMARKERS ; CHALLENGE ; TOXICANTS ; MIXTURES |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23496 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA; 2.Univ Washington, Inst Risk Anal & Risk Commun, Seattle, WA 98195 USA |
推荐引用方式 GB/T 7714 | Shaffer, Rachel M.,Smith, Marissa N.,Faustman, Elaine M.. Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Shaffer, Rachel M.,Smith, Marissa N.,&Faustman, Elaine M..(2017).Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS).ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Shaffer, Rachel M.,et al."Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS)".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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