Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1274 |
New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures | |
Harrill, Alison H.1; McAllister, Kimberly A.2 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: This paper provides an introduction for environmental health scientists to emerging population-based rodent resources. Mouse reference populations provide an opportunity to model environmental exposures and gene environment interactions in human disease and to inform human health risk assessment. OBJECTIVES: This review will describe several mouse populations for toxicity assessment, including older models such as the Mouse Diversity Panel (MDP), and newer models that include the Collaborative Cross (CC) and Diversity Outbred (DO) models. METHODS: This review will outline the features of the MDP, CC, and DO mouse models and will discuss published case studies investigating the use of these mouse population resources in each step of the risk assessment paradigm. DISCUSSION: These unique resources have the potential to be powerful tools for generating hypotheses related to gene environment interplay in human disease, performing controlled exposure studies to understand the differential responses in humans for susceptibility or resistance to environmental exposures, and identifying gene variants that influence sensitivity to toxicity and disease states. CONCLUSIONS: These new resources offer substantial advances to classical toxicity testing paradigms by including genetically sensitive individuals that may inform toxicity risks for sensitive subpopulations. Both in vivo and complementary in vitro resources provide platforms with which to reduce uncertainty by providing population-level data around biological variability. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600008 |
WOS关键词 | MOUSE DIVERSITY PANEL ; COLLABORATIVE CROSS ; TRICHLOROETHYLENE METABOLISM ; EPIGALLOCATECHIN GALLATE ; INTERSTRAIN VARIABILITY ; SUBSPECIFIC ORIGIN ; DRUG DEVELOPMENT ; NEXT-GENERATION ; TOXICITY ; MICE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23943 |
专题 | 资源环境科学 |
作者单位 | 1.NIEHS, Biomol Screening Branch, Div Natl Toxicol Program, NIH,Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA; 2.NIEHS, Genes Environm & Hlth Branch, Div Extramural Res & Training, NIH,Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Harrill, Alison H.,McAllister, Kimberly A.. New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Harrill, Alison H.,&McAllister, Kimberly A..(2017).New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Harrill, Alison H.,et al."New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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