Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP315 |
Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers | |
Hoppin, Jane A.1,2; Umbach, David M.3; Long, Stuart4; London, Stephanie J.5; Henneberger, Paul K.6; Blair, Aaron7; Alavanja, Michael7; Freeman, Laura E. Beane7; Sandler, Dale P.5 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Growing evidence suggests that pesticide use may contribute to respiratory symptoms. OBJECTIVE: We evaluated the association of currently used pesticides with allergic and non-allergic wheeze among male farmers. METHODS: Using the 2005-2010 interview data of the Agricultural Health Study, a prospective study of farmers in North Carolina and Iowa, we evaluated the association between allergic and non-allergic wheeze and self-reported use of 78 specific pesticides, reported by =1% of the 22,134 men interviewed. We used polytomous regression models adjusted for age, BMI, state, smoking, and current asthma, as well as for days applying pesticides and days driving diesel tractors. We defined allergic wheeze as reporting both wheeze and doctor-diagnosed hay fever (n=1,310, 6%) and non-allergic wheeze as reporting wheeze but not hay fever (n=3,939, 18%); men without wheeze were the referent. RESULTS: In models evaluating current use of specific pesticides, 19 pesticides were significantly associated (p< 0.05) with allergic wheeze (18 positive, 1 negative) and 21 pesticides with non-allergic wheeze (19 positive, 2 negative); 11 pesticides were associated with both. Seven pesticides (herbicides: 2,4-D and simazine; insecticides: carbaryl, dimethoate, disulfoton, and zeta-cypermethrin; and fungicide pyraclostrobin) had significantly different associations for allergic and non-allergic wheeze. In exposure-response models with up to five exposure categories, we saw evidence of an exposure-response relationship for several pesticides including the commonly used herbicides 2,4-D and glyphosate, the insecticides permethrin and carbaryl, and the rodenticide warfarin. CONCLUSIONS: These results for farmers implicate several pesticides that are commonly used in agricultural and residential settings with adverse respiratory effects. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400013 |
WOS关键词 | INDUCED AIRWAY HYPERREACTIVITY ; AGRICULTURAL HEALTH ; RESPIRATORY SYMPTOMS ; ASTHMA ; EXPOSURE ; APPLICATORS ; ORGANOPHOSPHORUS ; INSECTICIDES ; INFLAMMATION ; CARBARYL |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24165 |
专题 | 资源环境科学 |
作者单位 | 1.North Carolina State Univ, Dept Biol Sci, Toxicol Bldg,1104L,Box 7633, Raleigh, NC 27695 USA; 2.North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC USA; 3.NIEHS, Biostat & Computat Biol Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA; 4.Westat Corp, Durham, NC USA; 5.NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA; 6.NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA; 7.NCI, NIH, US Dept HHS, Rockville, MD USA |
推荐引用方式 GB/T 7714 | Hoppin, Jane A.,Umbach, David M.,Long, Stuart,et al. Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Hoppin, Jane A..,Umbach, David M..,Long, Stuart.,London, Stephanie J..,Henneberger, Paul K..,...&Sandler, Dale P..(2017).Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Hoppin, Jane A.,et al."Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
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