Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies

doi:10.1289/EHP376

GSTDTAP > 资源环境科学

DOI	10.1289/EHP376
	Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies
	Rava, Marta 1,2; Ahmed, Ismail 3,4,5; Kogevinas, Manolis 6,7; Le Moual, Nicole 1,8; Bouzigon, Emmanuelle 9,10; Curjuric, Ivan 11,12; Dizier, Marie-Helene 9,10; Dumas, Orianne 1; Gonzalez, Juan R.6,7; Imboden, Medea 11,12; Mehta, Amar J.11,12,13; Tubert-Bitter, Pascale 3,4,5; Zock, Jan-Paul 6,7,14; Jarvis, Deborah 15,16; Probst-Hensch, Nicole M.11,12; Demenais, Florence 9,10; Nadif, Rachel 1,8
	2017-02-01
发表期刊	ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN	0091-6765
EISSN	1552-9924
出版年	2017
卷号	125 期号:2
文章类型	Article
语种	英语
国家	France; Spain; Switzerland; USA; England
英文摘要	BACKGROUND: The biological mechanisms by which cleaning products and disinfectants-an emerging risk factor-affect respiratory health remain incompletely evaluated. Studying genes by environment interactions (G x E) may help identify new genes related to adult-onset asthma. OBJECTIVES: We identified interactions between genetic polymorphisms of a large set of genes involved in the response to oxidative stress and occupational exposures to low molecular weight (LMW) agents or irritants on adult-onset asthma. METHODS: Our data came from three large European cohorts: Epidemiological Family-based Study of the Genetics and Environment of Asthma (EGEA), Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA), and European Community Respiratory Health Survey in Adults (ECRHS). A candidate pathway-based strategy identified 163 genes involved in the response to oxidative stress and potentially related to exposures to LMW agents/irritants. Occupational exposures were evaluated using an asthma job-exposure matrix and job-specific questionnaires for cleaners and healthcare workers. Logistic regression models were used to detect G x E interactions, adjusted for age, sex, and population ancestry, in 2,599 adults (mean age, 47 years; 60% women, 36% exposed, 18% asthmatics). p-Values were corrected for multiple comparisons. Results: Ever exposure to LMW agents/ irritants was associated with current adult-onset asthma [OR = 1.28 (95% CI: 1.04, 1.58)]. Eight single nucleotide polymorphism (SNP) by exposure interactions at five loci were found at p < 0.005: PLA2G4A (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2), near RELA (rs931127, rs7949980, chromosome 11), PRKD1 (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA (rs6504453, chromosome 17). RESULTS were consistent across the three studies and after accounting for smoking. CONCLUSIONS: Using a pathway-based selection process, we identified novel genes potentially involved in adult asthma by interaction with occupational exposure. These genes play a role in the NF-.B pathway, which is involved in inflammation.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000394004000014
WOS关键词	OBSTRUCTIVE PULMONARY-DISEASE ; GENOME-WIDE ASSOCIATION ; ENVIRONMENT INTERACTION ; AIR-POLLUTION ; CLEANING PRODUCTS ; EMERGING ROLES ; LUNG-FUNCTION ; SWISS COHORT ; WORKPLACE ; GENETICS
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/24233
专题	资源环境科学
作者单位	1.INSERM, VIMA Aging & Chron Dis Epidemiol & Publ Hlth App, U1168, 16 Ave Paul Vaillant Couturier, F-94807 Villejuif, France; 2.Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Human Canc Genet Program, Madrid, Spain; 3.INSERM, UMR Biostat Biomath Pharmacoepidemiol & Infect Di, Villejuif, France; 4.Inst Pasteur, UMR 1181, B2PHI, Paris, France; 5.Univ Versailles St Quentin En Yvelines, UMR 1181, B2PHI, Montigny Le Bretonneux, France; 6.ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain; 7.CIBER Epidemiol Salud Publ, Madrid, Spain; 8.Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France; 9.INSERM, Genet Variat & Human Dis Unit, UMR 946, Paris, France; 10.Univ Paris Diderot, Inst Univ Hematol, Sorbonne Paris Cite, Paris, France; 11.Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; 12.Univ Basel, CH-4003 Basel, Switzerland; 13.Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 14.UPF, Barcelona, Spain; 15.Imperial Coll, Resp Epidemiol & Publ Hlth, London, England; 16.Ctr Environm & Hlth, MRC HPA Med Res Council & Hlth Protect Agcy, London, England
推荐引用方式 GB/T 7714	Rava, Marta,Ahmed, Ismail,Kogevinas, Manolis,et al. Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(2).
APA	Rava, Marta.,Ahmed, Ismail.,Kogevinas, Manolis.,Le Moual, Nicole.,Bouzigon, Emmanuelle.,...&Nadif, Rachel.(2017).Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies.ENVIRONMENTAL HEALTH PERSPECTIVES,125(2).
MLA	Rava, Marta,et al."Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies".ENVIRONMENTAL HEALTH PERSPECTIVES 125.2(2017).