Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1306/06201615130 |
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan | |
Han, Shuo1,2; Schroeder, Elizabeth A.1; Silva-Garica, Carlos G.3; Hebestreit, Katja1; Mair, William B.3; Brunet, Anne1,4 | |
2017-04-13 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 544期号:7649页码:185-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Chromatin and metabolic states both influence lifespan, but how they interact in lifespan regulation is largely unknown. The COMPASS chromatin complex, which trimethylates lysine 4 on histone H3 (H3K4me3), regulates lifespan in Caenorhabditis elegans. However, the mechanism by which H3K4me3 modifiers affect longevity, and whether this mechanism involves metabolic changes, remain unclear. Here we show that a deficiency in H3K4me3 methyltransferase, which extends lifespan, promotes fat accumulation in worms with a specific enrichment of mono-unsaturated fatty acids (MUFAs). This fat metabolism switch in H3K4me3 methyltransferase-deficient worms is mediated at least in part by the downregulation of germline targets, including S6 kinase, and by the activation of an intestinal transcriptional network that upregulates delta-9 fatty acid desaturases. Notably, the accumulation of MUFAs is necessary for the lifespan extension of H3K4me3 methyltransferase-deficient worms, and dietary MUFAs are sufficient to extend lifespan. Given the conservation of lipid metabolism, dietary or endogenous MUFAs could extend lifespan and healthspan in other species, including mammals. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398897900028 |
WOS关键词 | CARDIOVASCULAR-DISEASE ; SUBUNIT ; GENE ; RNA ; IDENTIFICATION ; DESATURASE ; METABOLISM ; MECHANISMS ; EXPRESSION ; LONGEVITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24545 |
专题 | 地球科学 |
作者单位 | 1.Stanford Univ, Dept Genet, 300 Pasteur Dr, Stanford, CA 94305 USA; 2.Stanford Univ, Grad Program Genet, 300 Pasteur Dr, Stanford, CA 94305 USA; 3.Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA; 4.Stanford Univ, Glenn Labs Biol Aging, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Han, Shuo,Schroeder, Elizabeth A.,Silva-Garica, Carlos G.,et al. Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan[J]. NATURE,2017,544(7649):185-+. |
APA | Han, Shuo,Schroeder, Elizabeth A.,Silva-Garica, Carlos G.,Hebestreit, Katja,Mair, William B.,&Brunet, Anne.(2017).Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.NATURE,544(7649),185-+. |
MLA | Han, Shuo,et al."Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan".NATURE 544.7649(2017):185-+. |
条目包含的文件 | 条目无相关文件。 |
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