Contributions of maternal and fetal antiviral immunity in congenital disease

doi:10.1126/science.aaz1960

GSTDTAP > 气候变化

DOI	10.1126/science.aaz1960
	Contributions of maternal and fetal antiviral immunity in congenital disease
	Laura J. Yockey; Carolina Lucas; Akiko Iwasaki
	2020-05-08
发表期刊	Science
出版年	2020
英文摘要	Viral infections during pregnancy can have devastating consequences on pregnancy outcomes, fetal development, and maternal health. In this review, we examine fetal and maternal immune defense mechanisms that mediate resistance against viral infections and discuss the range of syndromes that ensue when such mechanisms fail, from fetal developmental defects to establishment of chronic infection. Further, we highlight the role of maternal immune activation, or uncontrolled inflammation triggered by viral infections during pregnancy, and its potential downstream pathological effects, including tissue damage and fetal demise. Insights into the respective contributions of direct viral toxicity versus fetal and maternal immune responses that underlie the pathogenesis of congenital disease will guide future treatment strategies.
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/249722
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Laura J. Yockey,Carolina Lucas,Akiko Iwasaki. Contributions of maternal and fetal antiviral immunity in congenital disease[J]. Science,2020.
APA	Laura J. Yockey,Carolina Lucas,&Akiko Iwasaki.(2020).Contributions of maternal and fetal antiviral immunity in congenital disease.Science.
MLA	Laura J. Yockey,et al."Contributions of maternal and fetal antiviral immunity in congenital disease".Science (2020).