Vaccination strategies to enhance immunity in neonates

doi:10.1126/science.aaz9447

GSTDTAP > 气候变化

DOI	10.1126/science.aaz9447
	Vaccination strategies to enhance immunity in neonates
	Tobias R. Kollmann; Arnaud Marchant; Sing Sing Way
	2020-05-08
发表期刊	Science
出版年	2020
英文摘要	Neonates are particularly susceptible to infection. This vulnerability occurs despite their responsiveness to most vaccines. However, current vaccines do not target the pathogens responsible for most of the severe neonatal infections, and the time it takes to induce protective pathogen-specific immunity after vaccination limits protection in the first days to weeks of life. Alternative strategies include using vaccines to broadly stimulate neonatal immunity in a pathogen-agnostic fashion or vaccinating women during pregnancy to induce protective antibodies that are vertically transferred to offspring within their window of vulnerability. Protection may be further improved by integrating these approaches, namely vaccinating the neonate under the cover of vertically transferred maternal immunity. The rationale for and knowledge gaps related to each of these alternatives are discussed.
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/249727
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Tobias R. Kollmann,Arnaud Marchant,Sing Sing Way. Vaccination strategies to enhance immunity in neonates[J]. Science,2020.
APA	Tobias R. Kollmann,Arnaud Marchant,&Sing Sing Way.(2020).Vaccination strategies to enhance immunity in neonates.Science.
MLA	Tobias R. Kollmann,et al."Vaccination strategies to enhance immunity in neonates".Science (2020).