GSTDTAP  > 资源环境科学
DOI10.1038/s41467-020-15056-8
Inducible cell-to-cell signaling for tunable dynamics in microbial communities
Miano, Arianna1,2; Liao, Michael J.1,2; Hasty, Jeff1,2,3
2020-03-04
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2020
卷号11期号:1
文章类型Article
语种英语
国家USA
英文摘要

The last decade has seen bacteria at the forefront of biotechnological innovation, with applications including biomolecular computing, living therapeutics, microbiome engineering and microbial factories. These emerging applications are all united by the need to precisely control complex microbial dynamics in spatially extended environments, requiring tools that can bridge the gap between intracellular and population-level coordination. To address this need, we engineer an inducible quorum sensing system which enables precise tunability of bacterial dynamics both at the population and community level. As a proof-of-principle, we demonstrate the advantages of this system when genetically equipped for cargo delivery. In addition, we exploit the absence of cross-talk with respect to the majority of well-characterized quorum sensing systems to demonstrate inducibility of multi-strain communities. More broadly, this work highlights the unexplored potential of remotely inducible quorum sensing systems which, coupled to any gene of interest, may facilitate the translation of circuit designs into applications.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000549161100003
WOS关键词ENGINEERING BACTERIA ; QUORUM ; COMMUNICATION ; EXPRESSION ; SYSTEM
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/249744
专题资源环境科学
作者单位1.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA;
2.Univ Calif San Diego, BioCircuits Inst, La Jolla, CA 92093 USA;
3.Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA
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Miano, Arianna,Liao, Michael J.,Hasty, Jeff. Inducible cell-to-cell signaling for tunable dynamics in microbial communities[J]. NATURE COMMUNICATIONS,2020,11(1).
APA Miano, Arianna,Liao, Michael J.,&Hasty, Jeff.(2020).Inducible cell-to-cell signaling for tunable dynamics in microbial communities.NATURE COMMUNICATIONS,11(1).
MLA Miano, Arianna,et al."Inducible cell-to-cell signaling for tunable dynamics in microbial communities".NATURE COMMUNICATIONS 11.1(2020).
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