Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1002/2016GL071542 |
Molecular basis of ancestral vertebrate electroreception | |
Bellono, Nicholas W.; Leitch, Duncan B.; Julius, David | |
2017-03-16 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 543期号:7645页码:391-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Elasmobranch fishes, including sharks, rays, and skates, use specialized electrosensory organs called ampullae of Lorenzini to detect extremely small changes in environmental electric fields. Electrosensory cells within these ampullae can discriminate and respond to minute changes in environmental voltage gradients through an unknown mechanism. Here we show that the voltage-gated calcium channel Ca(V)1.3 and the big conductance calcium-activated potassium (BK) channel are preferentially expressed by electrosensory cells in little skate (Leucoraja erinacea) and functionally couple to mediate electrosensory cell membrane voltage oscillations, which are important for the detection of specific, weak electrical signals. Both channels exhibit unique properties compared with their mammalian orthologues that support electrosensory functions: structural adaptations in Ca(V)1.3 mediate a low-voltage threshold for activation, and alterations in BK support specifically tuned voltage oscillations. These findings reveal a molecular basis of electroreception and demonstrate how discrete evolutionary changes in ion channel structure facilitate sensory adaptation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396337400044 |
WOS关键词 | OSCILLATORY RESPONSES ; LATERAL-LINE ; BK CHANNELS ; SKATE ; CONDUCTANCE ; CELLS ; SUBUNITS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/25542 |
专题 | 气候变化 |
作者单位 | Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Bellono, Nicholas W.,Leitch, Duncan B.,Julius, David. Molecular basis of ancestral vertebrate electroreception[J]. NATURE,2017,543(7645):391-+. |
APA | Bellono, Nicholas W.,Leitch, Duncan B.,&Julius, David.(2017).Molecular basis of ancestral vertebrate electroreception.NATURE,543(7645),391-+. |
MLA | Bellono, Nicholas W.,et al."Molecular basis of ancestral vertebrate electroreception".NATURE 543.7645(2017):391-+. |
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