Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish

doi:10.1126/science.aba5216

GSTDTAP > 气候变化

DOI	10.1126/science.aba5216
	Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish
	Daniel L. Powell; Mateo García-Olazábal; Mackenzie Keegan; Patrick Reilly; Kang Du; Alejandra P. Díaz-Loyo; Shreya Banerjee; Danielle Blakkan; David Reich; Peter Andolfatto; Gil G. Rosenthal; Manfred Schartl; Molly Schumer
	2020-05-15
发表期刊	Science
出版年	2020
英文摘要	Deleterious gene interactions may underlie the observed hybrid incompatibilities. However, few genes underlying hybrid incompatibilities have been identified, and most of these involve species that do not hybridize in natural conditions. Powell et al. used genome sequencing to map genes likely responsible for incompatibilities that reduce fitness in naturally occurring hybrid swordtail fish. These gene combinations result in malignant melanoma, which is found in naturally hybridizing populations but is not present in the parental populations (see the Perspective by Dagilis and Matute). Using genome and population resequencing, the authors performed a genome-wide association study to identify potentially causative mutations. Using an admixture mapping approach that assessed introgression between multiple swordtail fish species, the authors suggest that lineages carry different genes that interact with the same candidate gene, resulting in the observed melanomas and providing insight into convergent hybrid incompatibles that arise between species. Science , this issue p. [731][1]; see also p. [710][2] The establishment of reproductive barriers between populations can fuel the evolution of new species. A genetic framework for this process posits that “incompatible” interactions between genes can evolve that result in reduced survival or reproduction in hybrids. However, progress has been slow in identifying individual genes that underlie hybrid incompatibilities. We used a combination of approaches to map the genes that drive the development of an incompatibility that causes melanoma in swordtail fish hybrids. One of the genes involved in this incompatibility also causes melanoma in hybrids between distantly related species. Moreover, this melanoma reduces survival in the wild, likely because of progressive degradation of the fin. This work identifies genes underlying a vertebrate hybrid incompatibility and provides a glimpse into the action of these genes in natural hybrid populations. [1]: /lookup/doi/10.1126/science.aba5216 [2]: /lookup/doi/10.1126/science.abb8066
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/267713
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Daniel L. Powell,Mateo García-Olazábal,Mackenzie Keegan,et al. Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish[J]. Science,2020.
APA	Daniel L. Powell.,Mateo García-Olazábal.,Mackenzie Keegan.,Patrick Reilly.,Kang Du.,...&Molly Schumer.(2020).Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.Science.
MLA	Daniel L. Powell,et al."Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish".Science (2020).