The human tumor microbiome is composed of tumor type–specific intracellular bacteria

doi:10.1126/science.aay9189

GSTDTAP > 气候变化

DOI	10.1126/science.aay9189
	The human tumor microbiome is composed of tumor type–specific intracellular bacteria
	Deborah Nejman; Ilana Livyatan; Garold Fuks; Nancy Gavert; Yaara Zwang; Leore T. Geller; Aviva Rotter-Maskowitz; Roi Weiser; Giuseppe Mallel; Elinor Gigi; Arnon Meltser; Gavin M. Douglas; Iris Kamer; Vancheswaran Gopalakrishnan; Tali Dadosh; Smadar Levin-Zaidman; Sofia Avnet; Tehila Atlan; Zachary A. Cooper; Reetakshi Arora; Alexandria P. Cogdill; Md Abdul Wadud Khan; Gabriel Ologun; Yuval Bussi; Adina Weinberger; Maya Lotan-Pompan; Ofra Golani; Gili Perry; Merav Rokah; Keren Bahar-Shany; Elisa A. Rozeman; Christian U. Blank; Anat Ronai; Ron Shaoul; Amnon Amit; Tatiana Dorfman; Ran Kremer; Zvi R. Cohen; Sagi Harnof; Tali Siegal; Einav Yehuda-Shnaidman; Einav Nili Gal-Yam; Hagit Shapira; Nicola Baldini; Morgan G. I. Langille; Alon Ben-Nun; Bella Kaufman; Aviram Nissan; Talia Golan; Maya Dadiani; Keren Levanon; Jair Bar; Shlomit Yust-Katz; Iris Barshack; Daniel S. Peeper; Dan J. Raz; Eran Segal; Jennifer A. Wargo; Judith Sandbank; Noam Shental; Ravid Straussman
	2020-05-29
发表期刊	Science
出版年	2020
英文摘要	Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al. produced an exhaustive catalog of the bacteria present in more than 1500 human tumors representing seven different tumor types (see the Perspective by Atreya and Turnbaugh). They found that the bacteria within tumors were localized within both cancer cells and immune cells and that the bacterial composition varied according to tumor type. Certain biologically plausible associations were identified. For example, breast cancer subtypes characterized by increased oxidative stress were enriched in bacteria that produce mycothiol, which can detoxify reactive oxygen species. Science , this issue p. [973][1]; see also p. [938][2] Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients’ smoking status, and the response to immunotherapy. [1]: /lookup/doi/10.1126/science.aay9189 [2]: /lookup/doi/10.1126/science.abc1464
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/271755
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Deborah Nejman,Ilana Livyatan,Garold Fuks,等. The human tumor microbiome is composed of tumor type–specific intracellular bacteria[J]. Science,2020.
APA	Deborah Nejman.,Ilana Livyatan.,Garold Fuks.,Nancy Gavert.,Yaara Zwang.,...&Ravid Straussman.(2020).The human tumor microbiome is composed of tumor type–specific intracellular bacteria.Science.
MLA	Deborah Nejman,et al."The human tumor microbiome is composed of tumor type–specific intracellular bacteria".Science (2020).