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DOI | 10.1126/science.aaz5887 |
Restoring light sensitivity using tunable near-infrared sensors | |
Dasha Nelidova; Rei K. Morikawa; Cameron S. Cowan; Zoltan Raics; David Goldblum; Hendrik P. N. Scholl; Tamas Szikra; Arnold Szabo; Daniel Hillier; Botond Roska | |
2020-06-05 | |
发表期刊 | Science
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出版年 | 2020 |
英文摘要 | Photoreceptor degeneration is an important cause of blindness. Nelidova et al. used tunable, near-infrared sensors to render diseased photoreceptors light sensitive again (see the Perspective by Franke and Vlasits). Gold nanorods capable of detecting infrared light were coupled with an antibody to temperature-sensitive ion channels. When the nanorods absorbed light and converted it into heat, the coupled ion channels were gated by infrared light. In a mouse model of retinal degeneration, these ion channels were successfully targeted to cone photoreceptors, and responses to near infrared light could be detected. In the primary visual cortex, more cells responded to near-infrared stimuli in mice expressing these ion channels than in controls. By changing the length of the gold nanorods, the system could be tuned to different infrared wavelengths. Science , this issue p. [1108][1]; see also p. [1057][2] Enabling near-infrared light sensitivity in a blind human retina may supplement or restore visual function in patients with regional retinal degeneration. We induced near-infrared light sensitivity using gold nanorods bound to temperature-sensitive engineered transient receptor potential (TRP) channels. We expressed mammalian or snake TRP channels in light-insensitive retinal cones in a mouse model of retinal degeneration. Near-infrared stimulation increased activity in cones, ganglion cell layer neurons, and cortical neurons, and enabled mice to perform a learned light-driven behavior. We tuned responses to different wavelengths, by using nanorods of different lengths, and to different radiant powers, by using engineered channels with different temperature thresholds. We targeted TRP channels to human retinas, which allowed the postmortem activation of different cell types by near-infrared light. [1]: /lookup/doi/10.1126/science.aaz5887 [2]: /lookup/doi/10.1126/science.abc2294 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/273443 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Dasha Nelidova,Rei K. Morikawa,Cameron S. Cowan,et al. Restoring light sensitivity using tunable near-infrared sensors[J]. Science,2020. |
APA | Dasha Nelidova.,Rei K. Morikawa.,Cameron S. Cowan.,Zoltan Raics.,David Goldblum.,...&Botond Roska.(2020).Restoring light sensitivity using tunable near-infrared sensors.Science. |
MLA | Dasha Nelidova,et al."Restoring light sensitivity using tunable near-infrared sensors".Science (2020). |
条目包含的文件 | 条目无相关文件。 |
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