Measles virus and rinderpest virus divergence dated to the sixth century BCE

doi:10.1126/science.aba9411

GSTDTAP > 气候变化

DOI	10.1126/science.aba9411
	Measles virus and rinderpest virus divergence dated to the sixth century BCE
	Ariane Düx; Sebastian Lequime; Livia Victoria Patrono; Bram Vrancken; Sengül Boral; Jan F. Gogarten; Antonia Hilbig; David Horst; Kevin Merkel; Baptiste Prepoint; Sabine Santibanez; Jasmin Schlotterbeck; Marc A. Suchard; Markus Ulrich; Navena Widulin; Annette Mankertz; Fabian H. Leendertz; Kyle Harper; Thomas Schnalke; Philippe Lemey; Sébastien Calvignac-Spencer
	2020-06-19
发表期刊	Science
出版年	2020
英文摘要	Animal domestication by humans is thought to have given many pathogens an opportunity to invade a new host, and measles is one example of this. However, there is controversy about when measles emerged in humans, because the historical descriptions of measles are relatively recent (late ninth century CE). The controversy has persisted in part because ancient RNA is thought to be a poor target for molecular clock techniques. Düx et al. have overcome the ancient RNA challenge by sequencing a measles virus genome obtained from a museum specimen of the lungs of child who died in 1912 (see the Perspective by Ho and Duchêne). The authors used these and other more recent sequencing data in a Bayesian molecular clock–modeling technique, which showed that measles virus diverged from rinderpest virus in the sixth century BCE, indicating an early origin for measles possibly associated with the beginnings of urbanization. Science , this issue p. [1367][1]; see also p. [1310][2] Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. This divergence date represents the earliest possible date for the establishment of measles in human populations. Our analyses show that the measles virus potentially arose as early as the sixth century BCE, possibly coinciding with the rise of large cities. [1]: /lookup/doi/10.1126/science.aba9411 [2]: /lookup/doi/10.1126/science.abc5746
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/276699
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ariane Düx,Sebastian Lequime,Livia Victoria Patrono,et al. Measles virus and rinderpest virus divergence dated to the sixth century BCE[J]. Science,2020.
APA	Ariane Düx.,Sebastian Lequime.,Livia Victoria Patrono.,Bram Vrancken.,Sengül Boral.,...&Sébastien Calvignac-Spencer.(2020).Measles virus and rinderpest virus divergence dated to the sixth century BCE.Science.
MLA	Ariane Düx,et al."Measles virus and rinderpest virus divergence dated to the sixth century BCE".Science (2020).