DOI | 10.1038/s41586-020-2115-1
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| Dopamine D2 receptors in discrimination learning and spine enlargement |
| Luo, Zhaochu1,2; Hrabec, Ales1,2,3; Dao, Trong Phuong1,2,3; Sala, Giacomo3; Finizio, Simone2; Feng, Junxiao3; Mayr, Sina1,2; Raabe, Joerg2; Gambardella, Pietro3; Heyderman, Laura J.1,2
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| 2020-03-01
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发表期刊 | NATURE
![](/C666/image/waiting.gif) |
ISSN | 0028-0836
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EISSN | 1476-4687
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出版年 | 2020
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卷号 | 579期号:7800页码:555-+ |
文章类型 | Article
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语种 | 英语
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国家 | Japan |
英文关键词 | Detection of dopamine dips by neurons that express dopamine D2 receptors in the striatum is used to refine generalized reward conditioning mediated by dopamine D1 receptors.
Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia(1,2). High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning(3-5). However, the nature and cellular basis of D2R-dependent behaviour are unclear. Here we show that tone reward conditioning induces marked stimulus generalization in a manner that depends on dopamine D1 receptors (D1Rs) in the nucleus accumbens (NAc) of mice, and that discrimination learning refines the conditioning using a dopamine dip. In NAc slices, a narrow dopamine dip (as short as 0.4 s) was detected by D2Rs to disinhibit adenosine A(2A) receptor (A(2A)R)-mediated enlargement of dendritic spines in D2R-expressing spiny projection neurons (D2-SPNs). Plasticity-related signalling by Ca2+/calmodulin-dependent protein kinase II and A(2A)Rs in the NAc was required for discrimination learning. By contrast, extinction learning did not involve dopamine dips or D2-SPNs. Treatment with methamphetamine, which dysregulates dopamine signalling, impaired discrimination learning and spine enlargement, and these impairments were reversed by a D2R antagonist. Our data show that D2Rs refine the generalized reward learning mediated by D1Rs.
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领域 | 地球科学
; 气候变化
; 资源环境
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收录类别 | SCI-E
; SSCI
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WOS记录号 | WOS:000520406700005
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WOS关键词 | STRUCTURAL PLASTICITY
; NEURONS
; PREDICTION
; NUCLEUS
; SENSITIZATION
; COCAINE
; METHAMPHETAMINE
; EXTINCTION
; ACTIVATION
; HYPOTHESIS
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WOS类目 | Multidisciplinary Sciences
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WOS研究方向 | Science & Technology - Other Topics
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引用统计 |
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文献类型 | 期刊论文
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条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281043
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专题 | 地球科学 资源环境科学 气候变化
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作者单位 | 1.Swiss Fed Inst Technol, Dept Mat, Lab Mesoscop Syst, Zurich, Switzerland; 2.Paul Scherrer Inst, Villigen, Switzerland; 3.Swiss Fed Inst Technol, Dept Mat, Lab Magnetism & Interface Phys, Zurich, Switzerland
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推荐引用方式 GB/T 7714 |
Luo, Zhaochu,Hrabec, Ales,Dao, Trong Phuong,et al. Dopamine D2 receptors in discrimination learning and spine enlargement[J].
NATURE,2020,579(7800):555-+.
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APA |
Luo, Zhaochu.,Hrabec, Ales.,Dao, Trong Phuong.,Sala, Giacomo.,Finizio, Simone.,...&Heyderman, Laura J..(2020).Dopamine D2 receptors in discrimination learning and spine enlargement.NATURE,579(7800),555-+.
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MLA |
Luo, Zhaochu,et al."Dopamine D2 receptors in discrimination learning and spine enlargement".NATURE 579.7800(2020):555-+.
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