An intestinal zinc sensor regulates food intake and developmental growth

doi:10.1038/s41586-020-2111-5

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2111-5
	An intestinal zinc sensor regulates food intake and developmental growth
	Wu, Thomas D.1; 39;Gorman, William E.2
	2020-03-01
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	580 期号:7802 页码:263-+
文章类型	Article
语种	英语
国家	England; USA; France; Germany
英文关键词	Hodor, an intestinal zinc-gated chloride channel, controls systemic growth in Drosophila by promoting food intake and by modulating Tor signalling and lysosomal homeostasis within enterocytes. In cells, organs and whole organisms, nutrient sensing is key to maintaining homeostasis and adapting to a fluctuating environment(1). In many animals, nutrient sensors are found within the enteroendocrine cells of the digestive system however, less is known about nutrient sensing in their cellular siblings, the absorptive enterocytes(1). Here we use a genetic screen in Drosophila melanogaster to identify Hodor, an ionotropic receptor in enterocytes that sustains larval development, particularly in nutrient-scarce conditions. Experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized dietary preference for zinc. Hodor controls systemic growth from a subset of enterocytes-interstitial cells-by promoting food intake and insulin/IGF signalling. Although Hodor sustains gut luminal acidity and restrains microbial loads, its effect on systemic growth results from the modulation of Tor signalling and lysosomal homeostasis within interstitial cells. Hodor-like genes are insect-specific, and may represent targets for the control of disease vectors. Indeed, CRISPR-Cas9 genome editing revealed that the single hodor orthologue in Anopheles gambiae is an essential gene. Our findings highlight the need to consider the instructive contributions of metals-and, more generally, micronutrients-to energy homeostasis.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000520406700008
WOS关键词	LYSOSOME-RELATED ORGANELLES ; COUPLES NUTRITION ; AMINO-ACIDS ; DROSOPHILA ; SECRETION ; MTORC1 ; HOMEOSTASIS ; METABOLISM ; MECHANISM ; SPECTRIN
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281105
专题	地球科学资源环境科学气候变化
作者单位	1.Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA; 2.Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA; 3.Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA; 4.Genentech Inc, Dept Microchem Prote Lipid & Next Generat Sequenc, San Francisco, CA 94080 USA; 5.Genentech Inc, Dept OMNI Biomarker Dev, San Francisco, CA 94080 USA; 6.Genentech Inc, Dept Res Biol, San Francisco, CA 94080 USA; 7.Genentech Inc, Dept Dev Sci, San Francisco, CA 94080 USA; 8.Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA; 9.ArsenalBio, San Francisco, CA 94080 USA
推荐引用方式 GB/T 7714	Wu, Thomas D.,39;Gorman, William E.. An intestinal zinc sensor regulates food intake and developmental growth[J]. NATURE,2020,580(7802):263-+.
APA	Wu, Thomas D.,&39;Gorman, William E..(2020).An intestinal zinc sensor regulates food intake and developmental growth.NATURE,580(7802),263-+.
MLA	Wu, Thomas D.,et al."An intestinal zinc sensor regulates food intake and developmental growth".NATURE 580.7802(2020):263-+.