Brain control of humoral immune responses amenable to behavioural modulation

doi:10.1038/s41586-020-2235-7

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2235-7
	Brain control of humoral immune responses amenable to behavioural modulation
	Yang, C. H.1; Leon, R. C. C.1; Hwang, J. C. C.1,7; Saraiva, A.1; Tanttu, T.1; Huang, W.1; Lemyre, J. Camirand 2,3; Chan, K. W.1; Tan, K. Y.4,8; Hudson, F. E.1; Itoh, K. M.5; Morello, A.1; Pioro-Ladriere, M.2,3,6; Laucht, A.1; Dzurak, A. S.1
	2020-04-16
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	581 期号:7807
文章类型	Article
语种	英语
国家	Peoples R China
英文关键词	It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune response. Splenic nerve activity enhances plasma cell production in a manner that requires B-cell responsiveness to acetylcholine mediated by the alpha 9 nicotinic receptor, and T cells that express choline acetyl transferase(1,2) probably act as a relay between the noradrenergic nerve and acetylcholine-responding B cells. We show that neurons in the central nucleus of the amygdala (CeA) and the paraventricular nucleus (PVN) that express corticotropin-releasing hormone (CRH) are connected to the splenic nerve ablation or pharmacogenetic inhibition of these neurons reduces plasma cell formation, whereas pharmacogenetic activation of these neurons increases plasma cell abundance after immunization. In a newly developed behaviour regimen, mice are made to stand on an elevated platform, leading to activation of CeA and PVN CRH neurons and increased plasma cell formation. In immunized mice, the elevated platform regimen induces an increase in antigen-specific IgG antibodies in a manner that depends on CRH neurons in the CeA and PVN, an intact splenic nerve, and B cell expression of the alpha 9 acetylcholine receptor. By identifying a specific brain-spleen neural connection that autonomically enhances humoral responses and demonstrating immune stimulation by a bodily behaviour, our study reveals brain control of adaptive immunity and suggests the possibility to enhance immunocompetency by behavioural intervention. Neuronal activities in the central amygdala and paraventricular nucleus are transmitted via the splenic nerve to increase plasma cell formation after immunization, and this process can be behaviourally enhanced in mice.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000529600400006
WOS关键词	ACETYLCHOLINE ; SYSTEM ; ACTIVATION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281195
专题	地球科学资源环境科学气候变化
作者单位	1.Univ New South Wales, Ctr Quantum Computat & Commun Technol, Sch Elect Engn & Telecommun, Sydney, NSW, Australia; 2.Univ Sherbrooke, Inst Quant, Sherbrooke, PQ, Canada; 3.Univ Sherbrooke, Dept Phys, Sherbrooke, PQ, Canada; 4.Aalto Univ, Dept Appl Phys, QTF Ctr Excellence, QCD Labs, Aalto, Finland; 5.Keio Univ, Sch Fundamental Sci & Technol, Yokohama, Kanagawa, Japan; 6.Canadian Inst Adv Res, Quantum Informat Sci Program, Toronto, ON, Canada; 7.Univ Sydney, Res & Prototype Foundry, Sydney, NSW, Australia; 8.IQM Finland Oy, Espoo, Finland
推荐引用方式 GB/T 7714	Yang, C. H.,Leon, R. C. C.,Hwang, J. C. C.,et al. Brain control of humoral immune responses amenable to behavioural modulation[J]. NATURE,2020,581(7807).
APA	Yang, C. H..,Leon, R. C. C..,Hwang, J. C. C..,Saraiva, A..,Tanttu, T..,...&Dzurak, A. S..(2020).Brain control of humoral immune responses amenable to behavioural modulation.NATURE,581(7807).
MLA	Yang, C. H.,et al."Brain control of humoral immune responses amenable to behavioural modulation".NATURE 581.7807(2020).