| DOI | 10.1038/s41586-020-2167-2
|
| A neural circuit mechanism for mechanosensory feedback control of ingestion |
| Field, Daniel J.1; Benito, Juan1,2; Chen, Albert1,2; Jagt, John W. M.3; Ksepka, Daniel T.4
|
| 2020-03-01
|
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836
|
| EISSN | 1476-4687
|
| 出版年 | 2020
|
| 卷号 | 580期号:7803页码:376-+ |
| 文章类型 | Article
|
| 语种 | 英语
|
| 国家 | South Korea; USA |
| 英文关键词 | Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut-brain communication pathways and mechanisms remain poorly understood(1-12). Here we show that, in mice, neurons in the parabrachial nucleus that express the prodynorphin gene (hereafter, PBPdyn neurons) monitor the intake of both fluids and solids, using mechanosensory signals that arise from the upper digestive tract. Most individual PBPdyn neurons are activated by ingestion as well as the stimulation of the mouth and stomach, which indicates the representation of integrated sensory signals across distinct parts of the digestive tract. PBPdyn neurons are anatomically connected to the digestive periphery via cranial and spinal pathways
we show that, among these pathways, the vagus nerve conveys stomach-distension signals to PBPdyn neurons. Upon receipt of these signals, these neurons produce aversive and sustained appetite-suppressing signals, which discourages the initiation of feeding and drinking (fully recapitulating the symptoms of gastric distension) in part via signalling to the paraventricular hypothalamus. By contrast, inhibiting the same population of PBPdyn neurons induces overconsumption only if a drive for ingestion exists, which confirms that these neurons mediate negative feedback signalling. Our findings reveal a neural mechanism that underlies the mechanosensory monitoring of ingestion and negative feedback control of intake behaviours upon distension of the digestive tract.
|
| 领域 | 地球科学
; 气候变化
; 资源环境
|
| 收录类别 | SCI-E
|
| WOS记录号 | WOS:000530151300030
|
| WOS关键词 | GUT-BRAIN COMMUNICATION
; PARABRACHIAL NUCLEUS
; GENETIC IDENTIFICATION
; SENSORY NEURONS
; VAGAL
; FLUID
; DYNAMICS
; THIRST
; SATIATION
; RESPONSES
|
| WOS类目 | Multidisciplinary Sciences
|
| WOS研究方向 | Science & Technology - Other Topics
|
| 引用统计 |
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281239
|
| 专题 | 地球科学
资源环境科学
气候变化
|
| 作者单位 | 1.Univ Cambridge, Dept Earth Sci, Cambridge, England;
2.Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England;
3.Nat Hist Museum Maastricht, Maastricht, Netherlands;
4.Bruce Museum, Greenwich, CT USA
|
推荐引用方式
GB/T 7714 |
Field, Daniel J.,Benito, Juan,Chen, Albert,et al. A neural circuit mechanism for mechanosensory feedback control of ingestion[J].
NATURE,2020,580(7803):376-+.
|
| APA |
Field, Daniel J.,Benito, Juan,Chen, Albert,Jagt, John W. M.,&Ksepka, Daniel T..(2020).A neural circuit mechanism for mechanosensory feedback control of ingestion.NATURE,580(7803),376-+.
|
| MLA |
Field, Daniel J.,et al."A neural circuit mechanism for mechanosensory feedback control of ingestion".NATURE 580.7803(2020):376-+.
|
修改评论