Multispecific drugs herald a new era of biopharmaceutical innovation

doi:10.1038/s41586-020-2168-1

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2168-1
	Multispecific drugs herald a new era of biopharmaceutical innovation
	Gallego, Laura D.1; Schneider, Maren 1; Mittal, Chitvan 2; Romanauska, Anete 1; Carrillo, Ricardo M. Gudino 1; Schubert, Tobias 1; Pugh, B. Franklin 2; Koehler, Alwin 1
	2020-03-11
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	580 期号:7803 页码:329-338
文章类型	Review
语种	英语
国家	USA
英文关键词	The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century, coincident with marketing of aspirin-a signature event in the history of modern drug development. Although the archetypal discovery process did not change markedly in the first seven decades of the industry, the past fifty years have seen two successive waves of transformative innovation in the development of drug molecules: the rise of ' rational drug discovery' methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980s. An incipient fourth wave is the advent of multispecific drugs. The successful development of prospectively designed multispecific drugs has the potential to reconfigure our ideas of how target-based therapeutic molecules can work, and what it is possible to achieve with them. Here I review the two major classes of multispecific drugs: those that enrich a therapeutic agent at a particular site of action and those that link a therapeutic target to a biological effector. The latter class-being freed from the constraint of having to directly modulate the target upon binding-may enable access to components of the proteome that currently cannot be targeted by drugs.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000530151300022
WOS关键词	BLOOD-BRAIN-BARRIER ; BISPECIFIC MONOCLONAL-ANTIBODY ; IN-VIVO ; BREFELDIN-A ; T-CELLS ; SELECTIVE DEGRADATION ; STRUCTURAL BASIS ; TARGET ; LENALIDOMIDE ; THALIDOMIDE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281371
专题	地球科学资源环境科学气候变化
作者单位	1.Med Univ Vienna, Max Perutz Labs, VBC, Vienna, Austria; 2.Penn State Univ, Ctr Eukaryot Gene Regulat, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
推荐引用方式 GB/T 7714	Gallego, Laura D.,Schneider, Maren,Mittal, Chitvan,et al. Multispecific drugs herald a new era of biopharmaceutical innovation[J]. NATURE,2020,580(7803):329-338.
APA	Gallego, Laura D..,Schneider, Maren.,Mittal, Chitvan.,Romanauska, Anete.,Carrillo, Ricardo M. Gudino.,...&Koehler, Alwin.(2020).Multispecific drugs herald a new era of biopharmaceutical innovation.NATURE,580(7803),329-338.
MLA	Gallego, Laura D.,et al."Multispecific drugs herald a new era of biopharmaceutical innovation".NATURE 580.7803(2020):329-338.