GSTDTAP  > 地球科学
DOI10.5194/acp-17-11423-2017
Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors
Tuet, Wing Y.1; Chen, Yunle2; Fok, Shierly1; Champion, Julie A.1; Ng, Nga L.1,3
2017-09-26
发表期刊ATMOSPHERIC CHEMISTRY AND PHYSICS
ISSN1680-7316
EISSN1680-7324
出版年2017
卷号17期号:18
文章类型Article
语种英语
国家USA
英文摘要

Cardiopulmonary health implications resulting from exposure to secondary organic aerosols (SOA), which comprise a significant fraction of ambient particulate matter (PM), have received increasing interest in recent years. In this study, alveolar macrophages were exposed to SOA generated from the photooxidation of biogenic and anthropogenic precursors (isoprene, alpha-pinene, beta-caryophyllene, pentadecane, m-xylene, and naphthalene) under different formation conditions (RO2 + HO2 vs. RO2 + NO dominant, dry vs. humid). Various cellular responses were measured, including reactive oxygen and nitrogen species (ROS/RNS) production and secreted levels of cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). SOA precursor identity and formation condition affected all measured responses in a hydrocarbon-specific manner. With the exception of naphthalene SOA, cellular responses followed a trend where TNF-alpha levels reached a plateau with increasing IL-6 levels. ROS/RNS levels were consistent with relative levels of TNF-alpha and IL-6, due to their respective inflammatory and anti-inflammatory effects. Exposure to naphthalene SOA, whose aromatic-ring-containing products may trigger different cellular pathways, induced higher levels of TNF-alpha and ROS/RNS than suggested by the trend. Distinct cellular response patterns were identified for hydrocarbons whose photooxidation products shared similar chemical functionalities and structures, which suggests that the chemical structure (carbon chain length and functionalities) of photooxidation products may be important for determining cellular effects. A positive nonlinear correlation was also detected between ROS/RNS levels and previously measured DTT (dithiothreitol) activities for SOA samples. In the context of ambient samples collected during summer and winter in the greater Atlanta area, all laboratory-generated SOA produced similar or higher levels of ROS/RNS and DTT activities. These results suggest that the health effects of SOA are important considerations for understanding the health implications of ambient aerosols.


领域地球科学
收录类别SCI-E
WOS记录号WOS:000411738000003
WOS关键词OXYGEN SPECIES ROS ; ATMOSPHERIC PARTICULATE MATTER ; HUMIC-LIKE SUBSTANCES ; REACTIVE OXYGEN ; AIR-POLLUTION ; CHEMICAL-COMPOSITION ; OXIDATIVE STRESS ; ALVEOLAR MACROPHAGE ; HIGH-RESOLUTION ; CARDIOPULMONARY RESPONSE
WOS类目Environmental Sciences ; Meteorology & Atmospheric Sciences
WOS研究方向Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/28335
专题地球科学
作者单位1.Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA;
2.Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA;
3.Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA
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Tuet, Wing Y.,Chen, Yunle,Fok, Shierly,et al. Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors[J]. ATMOSPHERIC CHEMISTRY AND PHYSICS,2017,17(18).
APA Tuet, Wing Y.,Chen, Yunle,Fok, Shierly,Champion, Julie A.,&Ng, Nga L..(2017).Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors.ATMOSPHERIC CHEMISTRY AND PHYSICS,17(18).
MLA Tuet, Wing Y.,et al."Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors".ATMOSPHERIC CHEMISTRY AND PHYSICS 17.18(2017).
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