Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.5194/acp-17-11423-2017 |
Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors | |
Tuet, Wing Y.1; Chen, Yunle2; Fok, Shierly1; Champion, Julie A.1; Ng, Nga L.1,3 | |
2017-09-26 | |
发表期刊 | ATMOSPHERIC CHEMISTRY AND PHYSICS
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ISSN | 1680-7316 |
EISSN | 1680-7324 |
出版年 | 2017 |
卷号 | 17期号:18 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Cardiopulmonary health implications resulting from exposure to secondary organic aerosols (SOA), which comprise a significant fraction of ambient particulate matter (PM), have received increasing interest in recent years. In this study, alveolar macrophages were exposed to SOA generated from the photooxidation of biogenic and anthropogenic precursors (isoprene, alpha-pinene, beta-caryophyllene, pentadecane, m-xylene, and naphthalene) under different formation conditions (RO2 + HO2 vs. RO2 + NO dominant, dry vs. humid). Various cellular responses were measured, including reactive oxygen and nitrogen species (ROS/RNS) production and secreted levels of cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). SOA precursor identity and formation condition affected all measured responses in a hydrocarbon-specific manner. With the exception of naphthalene SOA, cellular responses followed a trend where TNF-alpha levels reached a plateau with increasing IL-6 levels. ROS/RNS levels were consistent with relative levels of TNF-alpha and IL-6, due to their respective inflammatory and anti-inflammatory effects. Exposure to naphthalene SOA, whose aromatic-ring-containing products may trigger different cellular pathways, induced higher levels of TNF-alpha and ROS/RNS than suggested by the trend. Distinct cellular response patterns were identified for hydrocarbons whose photooxidation products shared similar chemical functionalities and structures, which suggests that the chemical structure (carbon chain length and functionalities) of photooxidation products may be important for determining cellular effects. A positive nonlinear correlation was also detected between ROS/RNS levels and previously measured DTT (dithiothreitol) activities for SOA samples. In the context of ambient samples collected during summer and winter in the greater Atlanta area, all laboratory-generated SOA produced similar or higher levels of ROS/RNS and DTT activities. These results suggest that the health effects of SOA are important considerations for understanding the health implications of ambient aerosols. |
领域 | 地球科学 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411738000003 |
WOS关键词 | OXYGEN SPECIES ROS ; ATMOSPHERIC PARTICULATE MATTER ; HUMIC-LIKE SUBSTANCES ; REACTIVE OXYGEN ; AIR-POLLUTION ; CHEMICAL-COMPOSITION ; OXIDATIVE STRESS ; ALVEOLAR MACROPHAGE ; HIGH-RESOLUTION ; CARDIOPULMONARY RESPONSE |
WOS类目 | Environmental Sciences ; Meteorology & Atmospheric Sciences |
WOS研究方向 | Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/28335 |
专题 | 地球科学 |
作者单位 | 1.Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA; 2.Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA; 3.Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA |
推荐引用方式 GB/T 7714 | Tuet, Wing Y.,Chen, Yunle,Fok, Shierly,et al. Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors[J]. ATMOSPHERIC CHEMISTRY AND PHYSICS,2017,17(18). |
APA | Tuet, Wing Y.,Chen, Yunle,Fok, Shierly,Champion, Julie A.,&Ng, Nga L..(2017).Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors.ATMOSPHERIC CHEMISTRY AND PHYSICS,17(18). |
MLA | Tuet, Wing Y.,et al."Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors".ATMOSPHERIC CHEMISTRY AND PHYSICS 17.18(2017). |
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