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Earth's spin axis follows the maximum moment of inertia axis of mantle convection, with some delay due to adjustment of the rotational bulge. Here we compute this axis for geodynamic models based on subduction history, assuming constant slab sinking speed, with another contribution due to thermochemical piles. For a wide range of parameters, a large shift of approximate to 90 degrees is predicted around 80-90Ma. It can be largely attributed to a change in circum-Pacific subduction from predominantly in the North and South toward East and West. Actual amounts of true polar wander are much smaller, pointing toward additional inertia tensor contributions, possibly due to slabs in the lowermost mantle below both polar regions. These slabs would have been subducted before approximate to 150Ma, when plate motions in the Panthalassa basin are largely unknown. Matching predicted and observed true polar wander can serve at constraining such plate motions.