Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity

doi:10.1126/science.abb3377

GSTDTAP > 气候变化

DOI	10.1126/science.abb3377
	Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity
	Zoltan Bozsoki; Kira Gysel; Simon B. Hansen; Damiano Lironi; Christina Krönauer; Feng Feng; Noor de Jong; Maria Vinther; Manoj Kamble; Mikkel B. Thygesen; Ebbe Engholm; Christian Kofoed; Sébastien Fort; John T. Sullivan; Clive W. Ronson; Knud J. Jensen; Mickaël Blaise; Giles Oldroyd; Jens Stougaard; Kasper R. Andersen; Simona Radutoiu
	2020-08-07
发表期刊	Science
出版年	2020
英文摘要	Lysine motif receptors in plants perceive glycans that signal the presence of pathogenic or symbiotic nitrogen-fixing microbes. Bozsoki et al. now define the portions of these receptors that create the discriminatory binding pocket (see the Perspective by Bisseling and Geurts). The motifs were conserved in receptors that initiate immune responses, reflecting the invariable nature of the chitin fragments that they sense. Conversely, the motifs in receptors that respond to symbiotic signals were more varied, reflecting the greater diversity of the lipochitooligosaccharides (Nod factors) that they sense. With domain swapping, the authors switched the Nod factor specificity of receptors from two legume species and also enabled a chitin receptor that was otherwise dedicated to the detection of pathogenic microbes to instead recognize Nod factors. Science , this issue p. [663][1]; see also p. [620][2] Plants evolved lysine motif (LysM) receptors to recognize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial colonization. We investigated how chitin and nodulation (Nod) factor receptors of Lotus japonicus initiate differential signaling of immunity or root nodule symbiosis. Two motifs in the LysM1 domains of these receptors determine specific recognition of ligands and discriminate between their in planta functions. These motifs define the ligand-binding site and make up the most structurally divergent regions in cognate Nod factor receptors. An adjacent motif modulates the specificity for Nod factor recognition and determines the selection of compatible rhizobial symbionts in legumes. We also identified how binding specificities in LysM receptors can be altered to facilitate Nod factor recognition and signaling from a chitin receptor, advancing the prospects of engineering rhizobial symbiosis into nonlegumes. [1]: /lookup/doi/10.1126/science.abb3377 [2]: /lookup/doi/10.1126/science.abd3857
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/288003
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Zoltan Bozsoki,Kira Gysel,Simon B. Hansen,et al. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity[J]. Science,2020.
APA	Zoltan Bozsoki.,Kira Gysel.,Simon B. Hansen.,Damiano Lironi.,Christina Krönauer.,...&Simona Radutoiu.(2020).Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity.Science.
MLA	Zoltan Bozsoki,et al."Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity".Science (2020).