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DOI | 10.1289/EHP6517 |
Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children | |
Clara Amalie Gade Timmermann; Kristoffer Jarlov Jensen; Flemming Nielsen; Esben Budtz-Jørgensen; Fiona van der Klis; Christine Stabell Benn; Philippe Grandjean; Ane Bærent Fisker | |
2020-08-10 | |
发表期刊 | Environmental Health Perspectives
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出版年 | 2020 |
英文摘要 | AbstractBackground:Perfluoroalkyl substances (PFAS) are a group of widely used persistent chemicals with suspected immunotoxic effects. Objectives:The present study aimed to examine the association between infant PFAS exposure and antibody responses to measles vaccination as well as morbidity in a low-income country. Methods:In a randomized controlled trial, children from Guinea-Bissau, West Africa, were followed from inclusion (4–7 months of age) through 2 years of age. Half the children received two measles vaccinations (at inclusion and at 9 months of age), and the other half received only one (at 9 months of age). In a subset of 237 children, six PFAS were quantified in serum at inclusion, and measles antibody concentrations were assessed at inclusion and at approximately 9 months and 2 years of age. At inclusion and at the 9-month visit, mothers were interviewed about infant morbidity. Results:All but one child had detectable serum concentrations of all six PFAS, although levels were lower than seen elsewhere. A doubling in perfluorooctane sulfonic acid (PFOS) and perfluorodecanoic acid (PFDA) were associated with 21% (95% CI: 2, 37%) and 25% (95% CI: 1, 43%), respectively, lower measles antibody concentrations at the 9-month visit among the children who had received a measles vaccine at inclusion. Elevated serum PFAS concentrations were also associated with reduced prevaccination measles antibody concentrations and increased morbidity. Discussion:The present study documents that PFAS exposure has reached West Africa and that infants show PFAS-associated increases in morbidity and decreases in measles-specific antibody concentrations before and after vaccination. These findings support the evidence on PFAS immunotoxicity at comparatively low serum concentrations. https://doi.org/10.1289/EHP6517 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/291047 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Clara Amalie Gade Timmermann,Kristoffer Jarlov Jensen,Flemming Nielsen,et al. Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children[J]. Environmental Health Perspectives,2020. |
APA | Clara Amalie Gade Timmermann.,Kristoffer Jarlov Jensen.,Flemming Nielsen.,Esben Budtz-Jørgensen.,Fiona van der Klis.,...&Ane Bærent Fisker.(2020).Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children.Environmental Health Perspectives. |
MLA | Clara Amalie Gade Timmermann,et al."Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children".Environmental Health Perspectives (2020). |
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