Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions

doi:10.1126/science.abc9004

GSTDTAP > 气候变化

DOI	10.1126/science.abc9004
	Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions
	Sheikh Taslim Ali; Lin Wang; Eric H. Y. Lau; Xiao-Ke Xu; Zhanwei Du; Ye Wu; Gabriel M. Leung; Benjamin J. Cowling
	2020-08-28
发表期刊	Science
出版年	2020
英文摘要	In epidemiology, serial intervals are measured from when one infected person starts to show symptoms to when the next person infected becomes symptomatic. For any specific infection, the serial interval is assumed to be a fixed characteristic. Using valuable transmission pair data for coronavirus disease (COVID-19) in mainland China, Ali et al. noticed that the average serial interval changed as nonpharmaceutical interventions were introduced. In mid-January 2020, serial intervals were on average 7.8 days, whereas in early February 2020, they decreased to an average of 2.2 days. The more quickly infected persons were identified and isolated, the shorter the serial interval became and the fewer the opportunities for virus transmission. The change in serial interval may not only measure the effectiveness of infection control interventions but may also indicate rising population immunity. Science , this issue p. [1106][1] Studies of novel coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have reported varying estimates of epidemiological parameters, including serial interval distributions—i.e., the time between illness onset in successive cases in a transmission chain—and reproduction numbers. By compiling a line-list database of transmission pairs in mainland China, we show that mean serial intervals of COVID-19 shortened substantially from 7.8 to 2.6 days within a month (9 January to 13 February 2020). This change was driven by enhanced nonpharmaceutical interventions, particularly case isolation. We also show that using real-time estimation of serial intervals allowing for variation over time provides more accurate estimates of reproduction numbers than using conventionally fixed serial interval distributions. These findings could improve our ability to assess transmission dynamics, forecast future incidence, and estimate the impact of control measures. [1]: /lookup/doi/10.1126/science.abc9004
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/293229
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Sheikh Taslim Ali,Lin Wang,Eric H. Y. Lau,et al. Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions[J]. Science,2020.
APA	Sheikh Taslim Ali.,Lin Wang.,Eric H. Y. Lau.,Xiao-Ke Xu.,Zhanwei Du.,...&Benjamin J. Cowling.(2020).Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions.Science.
MLA	Sheikh Taslim Ali,et al."Serial interval of SARS-CoV-2 was shortened over time by nonpharmaceutical interventions".Science (2020).