The evolutionary history of Neanderthal and Denisovan Y chromosomes

doi:10.1126/science.abb6460

GSTDTAP > 气候变化

DOI	10.1126/science.abb6460
	The evolutionary history of Neanderthal and Denisovan Y chromosomes
	Martin Petr; Mateja Hajdinjak; Qiaomei Fu; Elena Essel; Hélène Rougier; Isabelle Crevecoeur; Patrick Semal; Liubov V. Golovanova; Vladimir B. Doronichev; Carles Lalueza-Fox; Marco de la Rasilla; Antonio Rosas; Michael V. Shunkov; Maxim B. Kozlikin; Anatoli P. Derevianko; Benjamin Vernot; Matthias Meyer; Janet Kelso
	2020-09-25
发表期刊	Science
出版年	2020
英文摘要	The genomes of archaic hominins have been sequenced and compared with that of modern humans. However, most archaic individuals with high-quality sequences available have been female. Petr et al. performed targeted sequencing of the paternally inherited Y chromosomes from three Neanderthals and two Denisovans (see the Perspective by Schierup). Comparisons with available archaic and diverse modern human Y chromosomes indicated that, similar to the maternally inherited mitochondria, the human and Neanderthal Y chromosomes were more closely related to each other compared with the Denisovan Y chromosome. This result supports the conclusion that interbreeding between early humans and Neanderthals and selection replaced the more ancient Denisovian-like Y chromosome and mitochondria in Neanderthals. Science , this issue p. [1653][1]; see also p. [1565][2] Ancient DNA has provided new insights into many aspects of human history. However, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the majority of specimens that have been sequenced to sufficient coverage are female. Sequencing Y chromosomes from two Denisovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand years ago from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each other around 370 thousand years ago. The phylogenetic relationships of archaic and modern human Y chromosomes differ from the population relationships inferred from the autosomal genomes and mirror mitochondrial DNA phylogenies, indicating replacement of both the mitochondrial and Y chromosomal gene pools in late Neanderthals. This replacement is plausible if the low effective population size of Neanderthals resulted in an increased genetic load in Neanderthals relative to modern humans. [1]: /lookup/doi/10.1126/science.abb6460 [2]: /lookup/doi/10.1126/science.abe2766
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：62[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/296533
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Martin Petr,Mateja Hajdinjak,Qiaomei Fu,et al. The evolutionary history of Neanderthal and Denisovan Y chromosomes[J]. Science,2020.
APA	Martin Petr.,Mateja Hajdinjak.,Qiaomei Fu.,Elena Essel.,Hélène Rougier.,...&Janet Kelso.(2020).The evolutionary history of Neanderthal and Denisovan Y chromosomes.Science.
MLA	Martin Petr,et al."The evolutionary history of Neanderthal and Denisovan Y chromosomes".Science (2020).