Neurodegeneration

doi:10.1126/science.abe8398

GSTDTAP > 气候变化

DOI	10.1126/science.abe8398
	Neurodegeneration
	Stella Hurtley; Gemma Alderton
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	Neurodegeneration is an all-too-common set of symptoms seen in people as they reach life's later stages. Most famously, neurodegeneration can lead to memory loss, robbing people of their quality of life and their essential personality. Much fundamental research has led to a greater understanding of the pathophysiological processes involved in neurodegeneration and has revealed that accumulation of misfolded, toxic proteins is frequently a cause of neurodegeneration. This understanding is being refined toward the view that a common underlying principle of neurodegenerative misfolded proteins involves pathological phase transitions. Many different disorders can cause neurodegeneration, but by far the most prevalent is Alzheimer's disease. Much is already known about the genetic underpinnings of susceptibility to Alzheimer's disease, but there is still a lot to learn about how to translate this knowledge into therapies. Disrupted sleep often occurs before or in the early stages of neurogenerative disease. An important function of sleep is to allow waste products—including misfolded proteins associated with neurodegeneration—to be cleared from the brain via the glymphatic system. Microglia, the major tissue-resident immune cells of the brain, directly modulate neuronal function in development and in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Elucidating the biological foundations of neurodegenerative disease will be key to the development of targeted therapies to slow or prevent the onset of dementia. In such late-onset diseases, delaying symptoms by even a few years can make an enormous difference to the quality of life of patients, as well as their families and caregivers. Reviews Glymphatic failure as a final common pathway to dementia p. 50 Beyond aggregation: Pathological phase transitions in neurodegenerative disease p. 56 Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets p. 61 Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases p. 66 Related Item PERSPECTIVE p. 32
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298014
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Stella Hurtley,Gemma Alderton. Neurodegeneration[J]. Science,2020.
APA	Stella Hurtley,&Gemma Alderton.(2020).Neurodegeneration.Science.
MLA	Stella Hurtley,et al."Neurodegeneration".Science (2020).