Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

doi:10.1126/science.abb8587

GSTDTAP > 气候变化

DOI	10.1126/science.abb8587
	Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases
	Tim Bartels; Sebastiaan De Schepper; Soyon Hong
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer’s and Parkinson’s diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298026
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Tim Bartels,Sebastiaan De Schepper,Soyon Hong. Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases[J]. Science,2020.
APA	Tim Bartels,Sebastiaan De Schepper,&Soyon Hong.(2020).Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases.Science.
MLA	Tim Bartels,et al."Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases".Science (2020).