Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

doi:10.1126/science.abd3871

GSTDTAP > 气候变化

DOI	10.1126/science.abd3871
	Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
	Jose Mateus; Alba Grifoni; Alison Tarke; John Sidney; Sydney I. Ramirez; Jennifer M. Dan; Zoe C. Burger; Stephen A. Rawlings; Davey M. Smith; Elizabeth Phillips; Simon Mallal; Marshall Lammers; Paul Rubiro; Lorenzo Quiambao; Aaron Sutherland; Esther Dawen Yu; Ricardo da Silva Antunes; Jason Greenbaum; April Frazier; Alena J. Markmann; Lakshmanane Premkumar; Aravinda de Silva; Bjoern Peters; Shane Crotty; Alessandro Sette; Daniela Weiskopf
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	Robust T cell responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus occur in most individuals with coronavirus disease 2019 (COVID-19). Several studies have reported that some people who have not been exposed to SARS-CoV-2 have preexisting reactivity to SARS-CoV-2 sequences. The immunological mechanisms underlying this preexisting reactivity are not clear, but previous exposure to widely circulating common cold coronaviruses might be involved. Mateus et al. found that the preexisting reactivity against SARS-CoV-2 comes from memory T cells and that cross-reactive T cells can specifically recognize a SARS-CoV-2 epitope as well as the homologous epitope from a common cold coronavirus. These findings underline the importance of determining the impacts of preexisting immune memory in COVID-19 disease severity. Science , this issue p. [89][1] Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2–specific CD4+ T cell repertoire. We demonstrate a range of preexisting memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (COVID-19) disease. [1]: /lookup/doi/10.1126/science.abd3871
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298057
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jose Mateus,Alba Grifoni,Alison Tarke,et al. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans[J]. Science,2020.
APA	Jose Mateus.,Alba Grifoni.,Alison Tarke.,John Sidney.,Sydney I. Ramirez.,...&Daniela Weiskopf.(2020).Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.Science.
MLA	Jose Mateus,et al."Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans".Science (2020).