Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination

doi:10.1126/science.aaz8432

GSTDTAP > 气候变化

DOI	10.1126/science.aaz8432
	Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination
	Carl W. Davis; Katherine J. L. Jackson; Megan M. McCausland; Jaime Darce; Cathy Chang; Susanne L. Linderman; Chakravarthy Chennareddy; Rebecca Gerkin; Shantoria J. Brown; Jens Wrammert; Aneesh K. Mehta; Wan Cheung Cheung; Scott D. Boyd; Edmund K. Waller; Rafi Ahmed
	2020-10-09
发表期刊	Science
出版年	2020
英文摘要	The seasonal flu shot is currently recommended each year because the influenza viral strains in circulation are continuously changing and because the antibody responses produced by the vaccine decline over time. In a human study of healthy volunteers, Davis et al. tracked antibody responses after flu vaccination. They investigated whether the vaccine led to the generation of antibody-secreting plasma cells in the bone marrow, a lymphoid organ that supports the survival of these cells for years. Although vaccination did generate influenza-specific cells, most were short-lived and lost within 1 year. The fact that a small number did persist over 1 year raises prospects that the longevity of flu vaccines can be improved and provides key information for the development of universal vaccines against influenza. Science , this issue p. [237][1] A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPCs), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPCs 4 weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their prevaccination levels after 1 year. This decline was driven by the loss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained. Our results suggest that most BMPCs generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines. [1]: /lookup/doi/10.1126/science.aaz8432
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298105
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Carl W. Davis,Katherine J. L. Jackson,Megan M. McCausland,等. Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination[J]. Science,2020.
APA	Carl W. Davis.,Katherine J. L. Jackson.,Megan M. McCausland.,Jaime Darce.,Cathy Chang.,...&Rafi Ahmed.(2020).Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination.Science.
MLA	Carl W. Davis,et al."Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination".Science (2020).