Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1073/pnas.2012088117 |
Diatom modulation of select bacteria through use of two unique secondary metabolites | |
Ahmed A. Shibl; Ashley Isaac; Michael A. Ochsenkühn; Anny Cárdenas; Cong Fei; Gregory Behringer; Marc Arnoux; Nizar Drou; Miraflor P. Santos; Kristin C. Gunsalus; Christian R. Voolstra; Shady A. Amin | |
2020-10-16 | |
发表期刊 | Proceedings of the National Academy of Sciences
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出版年 | 2020 |
英文摘要 | Unicellular eukaryotic phytoplankton, such as diatoms, rely on microbial communities for survival despite lacking specialized compartments to house microbiomes (e.g., animal gut). Microbial communities have been widely shown to benefit from diatom excretions that accumulate within the microenvironment surrounding phytoplankton cells, known as the phycosphere. However, mechanisms that enable diatoms and other unicellular eukaryotes to nurture specific microbiomes by fostering beneficial bacteria and repelling harmful ones are mostly unknown. We hypothesized that diatom exudates may tune microbial communities and employed an integrated multiomics approach using the ubiquitous diatom Asterionellopsis glacialis to reveal how it modulates its naturally associated bacteria. We show that A. glacialis reprograms its transcriptional and metabolic profiles in response to bacteria to secrete a suite of central metabolites and two unusual secondary metabolites, rosmarinic acid and azelaic acid. While central metabolites are utilized by potential bacterial symbionts and opportunists alike, rosmarinic acid promotes attachment of beneficial bacteria to the diatom and simultaneously suppresses the attachment of opportunists. Similarly, azelaic acid enhances growth of beneficial bacteria while simultaneously inhibiting growth of opportunistic ones. We further show that the bacterial response to azelaic acid is numerically rare but globally distributed in the world’s oceans and taxonomically restricted to a handful of bacterial genera. Our results demonstrate the innate ability of an important unicellular eukaryotic group to modulate select bacteria in their microbial consortia, similar to higher eukaryotes, using unique secondary metabolites that regulate bacterial growth and behavior inversely across different bacterial populations. |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/299299 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Ahmed A. Shibl,Ashley Isaac,Michael A. Ochsenkühn,et al. Diatom modulation of select bacteria through use of two unique secondary metabolites[J]. Proceedings of the National Academy of Sciences,2020. |
APA | Ahmed A. Shibl.,Ashley Isaac.,Michael A. Ochsenkühn.,Anny Cárdenas.,Cong Fei.,...&Shady A. Amin.(2020).Diatom modulation of select bacteria through use of two unique secondary metabolites.Proceedings of the National Academy of Sciences. |
MLA | Ahmed A. Shibl,et al."Diatom modulation of select bacteria through use of two unique secondary metabolites".Proceedings of the National Academy of Sciences (2020). |
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