Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

doi:10.1126/science.aba4767

GSTDTAP > 气候变化

DOI	10.1126/science.aba4767
	Lineage analysis reveals an endodermal contribution to the vertebrate pituitary
	Peter Fabian; Kuo-Chang Tseng; Joanna Smeeton; Joseph J. Lancman; P. Duc Si Dong; Robert Cerny; J. Gage Crump
	2020-10-23
发表期刊	Science
出版年	2020
英文摘要	Placodes are specializations of the head ectoderm that are considered the source of many vertebrate novelties, including the nose, lens, ear, and hormone-producing portion of the pituitary. However, the presence of a pituitary-like structure in nonvertebrate chordates, derived instead from the endoderm, had suggested that the pituitary may predate placodes. Fabian et al. performed lineage tracing, time-lapse imaging, and single-cell messenger RNA sequencing to show that both endodermal and ectodermal cells can generate hormone-producing cells of the zebrafish pituitary. These experiments support that the vertebrate pituitary arises through interactions of an ancestral endodermal protopituitary with newly evolved placodal ectoderm. Science , this issue p. [463][1] Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head. The anterior-most placode generates the endocrine lobe [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reproduction. In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH. Single-cell RNA sequencing of the adult pituitary reveals similar competency of endodermal and ectodermal epithelia to generate all endocrine cell types. Further, endoderm can generate a rudimentary ADH-like structure in the near absence of ectodermal contributions. The fish condition supports the vertebrate pituitary arising through interactions of an ancestral endoderm-derived proto-pituitary with newly evolved placodal ectoderm. [1]: /lookup/doi/10.1126/science.aba4767
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/300298
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Peter Fabian,Kuo-Chang Tseng,Joanna Smeeton,et al. Lineage analysis reveals an endodermal contribution to the vertebrate pituitary[J]. Science,2020.
APA	Peter Fabian.,Kuo-Chang Tseng.,Joanna Smeeton.,Joseph J. Lancman.,P. Duc Si Dong.,...&J. Gage Crump.(2020).Lineage analysis reveals an endodermal contribution to the vertebrate pituitary.Science.
MLA	Peter Fabian,et al."Lineage analysis reveals an endodermal contribution to the vertebrate pituitary".Science (2020).