Resource conservation manifests in the genetic code

doi:10.1126/science.aaz9642

GSTDTAP > 气候变化

DOI	10.1126/science.aaz9642
	Resource conservation manifests in the genetic code
	Liat Shenhav; David Zeevi
	2020-11-06
发表期刊	Science
出版年	2020
英文摘要	The accumulation of mutations is typically limited by selective parameters. One such parameter is the elements needed to build proteins and molecules to maintain cells. Examining the underlying carbon, oxygen, and nitrogen content for different amino acids, Shenhav et al. examined the selective pressure resulting from nutrient limitation (see the Perspective by Polz and Cordero). The authors identified “resource-driven” selection as a purifying selective force associated with environmental nutrient availability, particularly nitrogen, and determined the impact of mutations on the organismal nutritional budget. From this constraint, the authors have proposed that the structure of the genetic code across organisms reflects the mutational impact on elemental resources. Science , this issue p. [683][1]; see also p. [655][2] Nutrient limitation drives competition for resources across organisms. However, much is unknown about how selective pressures resulting from nutrient limitation shape microbial coding sequences. Here, we study this “resource-driven selection” by using metagenomic and single-cell data of marine microbes, alongside environmental measurements. We show that a significant portion of the selection exerted on microbes is explained by the environment and is associated with nitrogen availability. Notably, this resource conservation optimization is encoded in the structure of the standard genetic code, providing robustness against mutations that increase carbon and nitrogen incorporation into protein sequences. This robustness generalizes to codon choices from multiple taxa across all domains of life, including the human genome. [1]: /lookup/doi/10.1126/science.aaz9642 [2]: /lookup/doi/10.1126/science.abf2588
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/301995
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Liat Shenhav,David Zeevi. Resource conservation manifests in the genetic code[J]. Science,2020.
APA	Liat Shenhav,&David Zeevi.(2020).Resource conservation manifests in the genetic code.Science.
MLA	Liat Shenhav,et al."Resource conservation manifests in the genetic code".Science (2020).