A marine microbiome antifungal targets urgent-threat drug-resistant fungi

doi:10.1126/science.abd6919

GSTDTAP > 气候变化

DOI	10.1126/science.abd6919
	A marine microbiome antifungal targets urgent-threat drug-resistant fungi
	Fan Zhang; Miao Zhao; Doug R. Braun; Spencer S. Ericksen; Jeff S. Piotrowski; Justin Nelson; Jian Peng; Gene E. Ananiev; Shaurya Chanana; Kenneth Barns; Jen Fossen; Hiram Sanchez; Marc G. Chevrette; Ilia A. Guzei; Changgui Zhao; Le Guo; Weiping Tang; Cameron R. Currie; Scott R. Rajski; Anjon Audhya; David R. Andes; Tim S. Bugni
	2020-11-20
发表期刊	Science
出版年	2020
英文摘要	Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt that produces a high diversity of chemical structures. They then screened these molecules for inhibition of fungi (see the Perspective by Cowen). A polycyclic molecule dubbed turbinmicin possessed potent antifungal activity against the multidrug-resistant fungal pathogens Candida auris and Aspergillus fumigatus . Preliminary mechanism-of-action and mouse toxicity studies suggest that this molecule works though a fungus-specific pathway and is well tolerated at therapeutic doses. Science , this issue p. [974][1]; see also p. [906][2] New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris. [1]: /lookup/doi/10.1126/science.abd6919 [2]: /lookup/doi/10.1126/science.abf1675
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/304406
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Fan Zhang,Miao Zhao,Doug R. Braun,et al. A marine microbiome antifungal targets urgent-threat drug-resistant fungi[J]. Science,2020.
APA	Fan Zhang.,Miao Zhao.,Doug R. Braun.,Spencer S. Ericksen.,Jeff S. Piotrowski.,...&Tim S. Bugni.(2020).A marine microbiome antifungal targets urgent-threat drug-resistant fungi.Science.
MLA	Fan Zhang,et al."A marine microbiome antifungal targets urgent-threat drug-resistant fungi".Science (2020).