Redox-active antibiotics enhance phosphorus bioavailability

doi:10.1126/science.abd1515

GSTDTAP > 气候变化

DOI	10.1126/science.abd1515
	Redox-active antibiotics enhance phosphorus bioavailability
	Darcy L. McRose; Dianne K. Newman
	2021-03-05
发表期刊	Science
出版年	2021
英文摘要	Bacteria secrete a wide range of small molecules with chemical reactivity that offers multiple functions in different contexts. Phenazines are commonly considered to be antibiotics, but they can also participate in environmental redox reactions, especially with iron. McRose and Newman found that phenazines, when added exogenously or made by bacteria in situ, can liberate phosphorous (P) in the form of phosphate from mineral surfaces, and that the production of these molecules is regulated by signaling pathways that respond to P limitation. Strains unable to produce these molecules grew more slowly under P limitation but could be rescued by the addition of exogenous phenazines. The authors hypothesize that reductive dissolution of iron oxides has the benefit of liberating P, and that this could be one mechanism of microbial P acquisition in some environments. Science , this issue p. [1033][1] Microbial production of antibiotics is common, but our understanding of their roles in the environment is limited. In this study, we explore long-standing observations that microbes increase the production of redox-active antibiotics under phosphorus limitation. The availability of phosphorus, a nutrient required by all life on Earth and essential for agriculture, can be controlled by adsorption to and release from iron minerals by means of redox cycling. Using phenazine antibiotic production by pseudomonads as a case study, we show that phenazines are regulated by phosphorus, solubilize phosphorus through reductive dissolution of iron oxides in the lab and field, and increase phosphorus-limited microbial growth. Phenazines are just one of many examples of phosphorus-regulated antibiotics. Our work suggests a widespread but previously unappreciated role for redox-active antibiotics in phosphorus acquisition and cycling. [1]: /lookup/doi/10.1126/science.abd1515
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/317000
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Darcy L. McRose,Dianne K. Newman. Redox-active antibiotics enhance phosphorus bioavailability[J]. Science,2021.
APA	Darcy L. McRose,&Dianne K. Newman.(2021).Redox-active antibiotics enhance phosphorus bioavailability.Science.
MLA	Darcy L. McRose,et al."Redox-active antibiotics enhance phosphorus bioavailability".Science (2021).