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DOI | 10.1126/science.abd1515 |
Redox-active antibiotics enhance phosphorus bioavailability | |
Darcy L. McRose; Dianne K. Newman | |
2021-03-05 | |
发表期刊 | Science
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出版年 | 2021 |
英文摘要 | Bacteria secrete a wide range of small molecules with chemical reactivity that offers multiple functions in different contexts. Phenazines are commonly considered to be antibiotics, but they can also participate in environmental redox reactions, especially with iron. McRose and Newman found that phenazines, when added exogenously or made by bacteria in situ, can liberate phosphorous (P) in the form of phosphate from mineral surfaces, and that the production of these molecules is regulated by signaling pathways that respond to P limitation. Strains unable to produce these molecules grew more slowly under P limitation but could be rescued by the addition of exogenous phenazines. The authors hypothesize that reductive dissolution of iron oxides has the benefit of liberating P, and that this could be one mechanism of microbial P acquisition in some environments. Science , this issue p. [1033][1] Microbial production of antibiotics is common, but our understanding of their roles in the environment is limited. In this study, we explore long-standing observations that microbes increase the production of redox-active antibiotics under phosphorus limitation. The availability of phosphorus, a nutrient required by all life on Earth and essential for agriculture, can be controlled by adsorption to and release from iron minerals by means of redox cycling. Using phenazine antibiotic production by pseudomonads as a case study, we show that phenazines are regulated by phosphorus, solubilize phosphorus through reductive dissolution of iron oxides in the lab and field, and increase phosphorus-limited microbial growth. Phenazines are just one of many examples of phosphorus-regulated antibiotics. Our work suggests a widespread but previously unappreciated role for redox-active antibiotics in phosphorus acquisition and cycling. [1]: /lookup/doi/10.1126/science.abd1515 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/317000 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Darcy L. McRose,Dianne K. Newman. Redox-active antibiotics enhance phosphorus bioavailability[J]. Science,2021. |
APA | Darcy L. McRose,&Dianne K. Newman.(2021).Redox-active antibiotics enhance phosphorus bioavailability.Science. |
MLA | Darcy L. McRose,et al."Redox-active antibiotics enhance phosphorus bioavailability".Science (2021). |
条目包含的文件 | 条目无相关文件。 |
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