Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1073/pnas.2017537118 |
Interventions can shift the thermal optimum for parasitic disease transmission | |
Karena H. Nguyen; Philipp H. Boersch-Supan; Rachel B. Hartman; Sandra Y. Mendiola; Valerie J. Harwood; David J. Civitello; Jason R. Rohr | |
2021-03-16 | |
发表期刊 | Proceedings of the National Academy of Sciences
![]() |
出版年 | 2021 |
英文摘要 | Temperature constrains the transmission of many pathogens. Interventions that target temperature-sensitive life stages, such as vector control measures that kill intermediate hosts, could shift the thermal optimum of transmission, thereby altering seasonal disease dynamics and rendering interventions less effective at certain times of the year and with global climate change. To test these hypotheses, we integrated an epidemiological model of schistosomiasis with empirically determined temperature-dependent traits of the human parasite Schistosoma mansoni and its intermediate snail host (Biomphalaria spp.). We show that transmission risk peaks at 21.7 °C (Topt), and simulated interventions targeting snails and free-living parasite larvae increased Topt by up to 1.3 °C because intervention-related mortality overrode thermal constraints on transmission. This Topt shift suggests that snail control is more effective at lower temperatures, and global climate change will increase schistosomiasis risk in regions that move closer to Topt. Considering regional transmission phenologies and timing of interventions when local conditions approach Topt will maximize human health outcomes. |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/318655 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Karena H. Nguyen,Philipp H. Boersch-Supan,Rachel B. Hartman,et al. Interventions can shift the thermal optimum for parasitic disease transmission[J]. Proceedings of the National Academy of Sciences,2021. |
APA | Karena H. Nguyen.,Philipp H. Boersch-Supan.,Rachel B. Hartman.,Sandra Y. Mendiola.,Valerie J. Harwood.,...&Jason R. Rohr.(2021).Interventions can shift the thermal optimum for parasitic disease transmission.Proceedings of the National Academy of Sciences. |
MLA | Karena H. Nguyen,et al."Interventions can shift the thermal optimum for parasitic disease transmission".Proceedings of the National Academy of Sciences (2021). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论