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DOI10.1126/science.abe0981
Early developmental asymmetries in cell lineage trees in living individuals
Liana Fasching; Yeongjun Jang; Simone Tomasi; Jeremy Schreiner; Livia Tomasini; Melanie V. Brady; Taejeong Bae; Vivekananda Sarangi; Nikolaos Vasmatzis; Yifan Wang; Anna Szekely; Thomas V. Fernandez; James F. Leckman; Alexej Abyzov; Flora M. Vaccarino
2021-03-19
发表期刊Science
出版年2021
英文摘要After fertilization, the human zygote divides into two cells. Fasching et al. used genomic analysis from cellular samples taken much later in development to back-calculate the cell division trees that went before. Although the first cell division in human development looks symmetrical from the outside, the fates followed by daughter cells from each of those first two blastomeres are anything but the same. As much as 90% of blood cells are derived from just one of the first two blastomeres. Science , this issue p. [1245][1] Mosaic mutations can be used to track cell lineages in humans. We used cell cloning to analyze embryonic cell lineages in two living individuals and a postmortem human specimen. Of 10 reconstructed postzygotic divisions, none resulted in balanced contributions of daughter lineages to tissues. In both living individuals, one of two lineages from the first cleavage was dominant across tissues, with 90% frequency in blood. We propose that the efficiency of DNA repair contributes to lineage imbalance. Allocation of lineages in postmortem brain correlated with anterior-posterior axis, associating lineage history with cell fate choices in embryos. We establish a minimally invasive framework for defining cell lineages in any living individual, which paves the way for studying their relevance in health and disease. [1]: /lookup/doi/10.1126/science.abe0981
领域气候变化 ; 资源环境
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/319936
专题气候变化
资源环境科学
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Liana Fasching,Yeongjun Jang,Simone Tomasi,et al. Early developmental asymmetries in cell lineage trees in living individuals[J]. Science,2021.
APA Liana Fasching.,Yeongjun Jang.,Simone Tomasi.,Jeremy Schreiner.,Livia Tomasini.,...&Flora M. Vaccarino.(2021).Early developmental asymmetries in cell lineage trees in living individuals.Science.
MLA Liana Fasching,et al."Early developmental asymmetries in cell lineage trees in living individuals".Science (2021).
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