Molecular mechanism of cytokinin-activated cell division in <em>Arabidopsis</em>

doi:10.1126/science.abe2305

GSTDTAP > 气候变化

DOI	10.1126/science.abe2305
	Molecular mechanism of cytokinin-activated cell division in Arabidopsis
	Weibing Yang; Sandra Cortijo; Niklas Korsbo; Pawel Roszak; Katharina Schiessl; Aram Gurzadyan; Raymond Wightman; Henrik Jönsson; Elliot Meyerowitz
	2021-03-26
发表期刊	Science
出版年	2021
英文摘要	The hormone cytokinin regulates various aspects of plant development and physiology, largely by managing cell proliferation. Yang et al. show that cytokinin promotes nuclear localization of the transcription factor MYB3R4, which activates the expression of two importins and genes that tip the cell into the next phase of the cell cycle. The importins facilitate further MYB3R4 accumulation within the nucleus, accelerating the progression into mitosis. MYB3R4 and the importins dissipate when the nuclear membrane dissolves at prometaphase, so there is only one round of mitotic activation per cell cycle. Science , this issue p. [1350][1] Mitogens trigger cell division in animals. In plants, cytokinins, a group of phytohormones derived from adenine, stimulate cell proliferation. Cytokinin signaling is initiated by membrane-associated histidine kinase receptors and transduced through a phosphorelay system. We show that in the Arabidopsis shoot apical meristem (SAM), cytokinin regulates cell division by promoting nuclear shuttling of Myb-domain protein 3R4 (MYB3R4), a transcription factor that activates mitotic gene expression. Newly synthesized MYB3R4 protein resides predominantly in the cytoplasm. At the G2-to-M transition, rapid nuclear accumulation of MYB3R4—consistent with an associated transient peak in cytokinin concentration—feeds a positive feedback loop involving importins and initiates a transcriptional cascade that drives mitosis and cytokinesis. An engineered nuclear-restricted MYB3R4 mimics the cytokinin effects of enhanced cell proliferation and meristem growth. [1]: /lookup/doi/10.1126/science.abe2305
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/321096
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Weibing Yang,Sandra Cortijo,Niklas Korsbo,et al. Molecular mechanism of cytokinin-activated cell division in Arabidopsis[J]. Science,2021.
APA	Weibing Yang.,Sandra Cortijo.,Niklas Korsbo.,Pawel Roszak.,Katharina Schiessl.,...&Elliot Meyerowitz.(2021).Molecular mechanism of cytokinin-activated cell division in Arabidopsis.Science.
MLA	Weibing Yang,et al."Molecular mechanism of cytokinin-activated cell division in Arabidopsis".Science (2021).