The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

doi:10.1126/science.abe7070

GSTDTAP > 气候变化

DOI	10.1126/science.abe7070
	The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage
	Kimberly A. Morrissey; Marcin Wegrecki; T. Praveena; Victoria L. Hansen; Lijing Bu; Komagal Kannan Sivaraman; Samuel Darko; Daniel C. Douek; Jamie Rossjohn; Robert D. Miller; Jérôme Le Nours
	2021-03-26
发表期刊	Science
出版年	2021
英文摘要	The two established T cell lineages found in jawed vertebrates use either an αβ or a γδ T cell receptor (TCR) to detect antigens. Recently, another type of TCR chain (TCRµ) was found in marsupials and monotremes. Morrissey et al. analyzed T cells from the gray short-tailed opossum and uncovered a third lineage resident in the spleen that uses a γµ TCR (see the Perspective by Criscitiello). The authors then characterized the crystal structures of two different γµ TCRs, which exhibited an architecture distinct from αβ or γδ TCRs in which a highly diverse, unpaired immunoglobulin-like variable domain was predicted to be the major antigen recognition determinant. Like camelid VHH and shark IgNAR antibodies, γµ TCRs could potentially inform future nanobody development. Science , this issue p. [1383][1]; see also p. [1308][2] αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR. [1]: /lookup/doi/10.1126/science.abe7070 [2]: /lookup/doi/10.1126/science.abg7639
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/321104
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Kimberly A. Morrissey,Marcin Wegrecki,T. Praveena,et al. The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage[J]. Science,2021.
APA	Kimberly A. Morrissey.,Marcin Wegrecki.,T. Praveena.,Victoria L. Hansen.,Lijing Bu.,...&Jérôme Le Nours.(2021).The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage.Science.
MLA	Kimberly A. Morrissey,et al."The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage".Science (2021).