Decoupling transcription factor expression and activity enables dimmer switch gene regulation

doi:10.1126/science.aba7582

GSTDTAP > 气候变化

DOI	10.1126/science.aba7582
	Decoupling transcription factor expression and activity enables dimmer switch gene regulation
	C. Ricci-Tam; I. Ben-Zion; J. Wang; J. Palme; A. Li; Y. Savir; M. Springer
	2021-04-16
发表期刊	Science
出版年	2021
英文摘要	A transcriptional control mechanism in yeast that allows cells to respond to changes in nutrient concentrations works very much like a household light-dimmer switch. That is, the system separately controls whether gene expression is “on” or “off” and the extent of gene expression. The galactose-responsive pathway is activated when yeast need to switch from metabolizing glucose to metabolizing galactose. Ricci-Tam et al. found that, rather than using two separate elements for the switch and dimmer controls, yeast use a single transcription factor, Gal4p, separately regulating its abundance (through transcriptional regulation) and its catalytic activity (through interaction with a protein-binding partner). Such regulation may be common and can allow responses to the environment on physiological and evolutionary time scales. Science , this issue p. [292][1] Gene-regulatory networks achieve complex mappings of inputs to outputs through mechanisms that are poorly understood. We found that in the galactose-responsive pathway in Saccharomyces cerevisiae , the decision to activate the transcription of genes encoding pathway components is controlled independently from the expression level, resulting in behavior resembling that of a mechanical dimmer switch. This was not a direct result of chromatin regulation or combinatorial control at galactose-responsive promoters; rather, this behavior was achieved by hierarchical regulation of the expression and activity of a single transcription factor. Hierarchical regulation is ubiquitous, and thus dimmer switch regulation is likely a key feature of many biological systems. Dimmer switch gene regulation may allow cells to fine-tune their responses to multi-input environments on both physiological and evolutionary time scales. [1]: /lookup/doi/10.1126/science.aba7582
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/322900
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	C. Ricci-Tam,I. Ben-Zion,J. Wang,et al. Decoupling transcription factor expression and activity enables dimmer switch gene regulation[J]. Science,2021.
APA	C. Ricci-Tam.,I. Ben-Zion.,J. Wang.,J. Palme.,A. Li.,...&M. Springer.(2021).Decoupling transcription factor expression and activity enables dimmer switch gene regulation.Science.
MLA	C. Ricci-Tam,et al."Decoupling transcription factor expression and activity enables dimmer switch gene regulation".Science (2021).