资源环境科技发展态势分析平台

"To reference a familiar phrase, it tells us that there is more than one way to bake a cake," said Jocelyn Colella, a postdoctoral researcher in evolutionary biology. "In other words, there are several ways for animals to adapt to desert conditions and discovering this genetic flexibility offers a silver lining to all species that will increasingly be forced to acclimate to hotter, drier settings."

In their study, recently published in the Journal of Heredity, researchers compared the genetic mechanisms of three species of mice found in warm and dry areas; the cactus and canyon mice, both found predominately in desert habitats, and the North American deer mouse, which can also be found in colder, wetter climates in the northern United States. The researchers hypothesized that similar genes in each species would be critical to survive in desert environments. What they found was that each species used a different mechanism, meaning different genes and functions allowing for the same adaptation. One species adapted through mutational genetic changes over time and another used changes in gene expression which can occur more quickly and may be the more efficient evolutionary route.

"We were excited by the findings because if our research had only found one gene that was critical to adapting to warmer, drier conditions it would suggest that it would be challenging for other animals to respond to climate change, but our work says there are multiple evolutionary options that enable desert survival," said Colella.

The findings could also provide foundational information for biomedical research in developing gene therapies for human kidney disease.

"Because mice are physiologically similar to humans, this type of evolutionary work offers important first steps toward identifying and understanding genes that control complex traits like dehydration, which can compromise human kidneys causing lifelong, irreparable damage," said Matt MacManes, associate professor of genome enabled biology.

Each year millions of people die of dehydration related illness around the world. Experts say even minor dehydration can compromise the kidneys causing lifelong issues.

This work was funded by the National Institute of Health National Institute of General Medical Sciences to M.D.M. (1R35GM128843).

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Materials provided by University of New Hampshire. Note: Content may be edited for style and length.

Journal Reference:

1. Jocelyn P Colella, Anna Tigano, Olga Dudchenko, Arina D Omer, Ruqayya Khan, Ivan D Bochkov, Erez L Aiden, Matthew D MacManes. Limited Evidence for Parallel Evolution Among Desert-AdaptedPeromyscusDeer Mice. Journal of Heredity, 2021; DOI: 10.1093/jhered/esab009