Investigate the origins of COVID-19

doi:10.1126/science.abj0016

GSTDTAP > 气候变化

DOI	10.1126/science.abj0016
	Investigate the origins of COVID-19
	Jesse D. Bloom; Yujia Alina Chan; Ralph S. Baric; Pamela J. Bjorkman; Sarah Cobey; Benjamin E. Deverman; David N. Fisman; Ravindra Gupta; Akiko Iwasaki; Marc Lipsitch; Ruslan Medzhitov; Richard A. Neher; Rasmus Nielsen; Nick Patterson; Tim Stearns; Erik van Nimwegen; Michael Worobey; David A. Relman
	2021-05-14
发表期刊	Science
出版年	2021
英文摘要	On 30 December 2019, the Program for Monitoring Emerging Diseases notified the world about a pneumonia of unknown cause in Wuhan, China ([ 1 ][1]). Since then, scientists have made remarkable progress in understanding the causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its transmission, pathogenesis, and mitigation by vaccines, therapeutics, and non-pharmaceutical interventions. Yet more investigation is still needed to determine the origin of the pandemic. Theories of accidental release from a lab and zoonotic spillover both remain viable. Knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks. In May 2020, the World Health Assembly requested that the World Health Organization (WHO) director-general work closely with partners to determine the origins of SARS-CoV-2 ([ 2 ][2]). In November, the Terms of Reference for a China–WHO joint study were released ([ 3 ][3]). The information, data, and samples for the study's first phase were collected and summarized by the Chinese half of the team; the rest of the team built on this analysis. Although there were no findings in clear support of either a natural spillover or a lab accident, the team assessed a zoonotic spillover from an intermediate host as “likely to very likely,” and a laboratory incident as “extremely unlikely” [([ 4 ][4]), p. 9]. Furthermore, the two theories were not given balanced consideration. Only 4 of the 313 pages of the report and its annexes addressed the possibility of a laboratory accident ([ 4 ][4]). Notably, WHO Director-General Tedros Ghebreyesus commented that the report's consideration of evidence supporting a laboratory accident was insufficient and offered to provide additional resources to fully evaluate the possibility ([ 5 ][5]). As scientists with relevant expertise, we agree with the WHO director-general ([ 5 ][5]), the United States and 13 other countries ([ 6 ][6]), and the European Union ([ 7 ][7]) that greater clarity about the origins of this pandemic is necessary and feasible to achieve. We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data. A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimize the impact of conflicts of interest. Public health agencies and research laboratories alike need to open their records to the public. Investigators should document the veracity and provenance of data from which analyses are conducted and conclusions drawn, so that analyses are reproducible by independent experts. Finally, in this time of unfortunate anti-Asian sentiment in some countries, we note that at the beginning of the pandemic, it was Chinese doctors, scientists, journalists, and citizens who shared with the world crucial information about the spread of the virus—often at great personal cost ([ 8 ][8], [ 9 ][9]). We should show the same determination in promoting a dispassionate science-based discourse on this difficult but important issue. 1. [↵][10]“Undiagnosed pneumonia—China (Hubei): Request for information,” ProMED post (2019); . 2. [↵][11]World Health Assembly Resolution 73.1: COVID-19 response (2020); [https://apps.who.int/gb/ebwha/pdf\_files/WHA73/A73\_R1-en.pdf][12]. 3. [↵][13]WHO, “WHO-convened global study of the origins of SARS-CoV-2” (2020); [www.who.int/publications/m/item/who-convened-global-study-of-the-origins-of-sars-cov-2][14]. 4. [↵][15]WHO, “WHO-convened global study of origins of SARS-CoV-2: China part” (2021); [www.who.int/publications/i/item/who-convened-global-study-of-origins-of-sars-cov-2-china-part][16]. 5. [↵][17]WHO, “WHO director-general's remarks at the Member State Briefing on the report of the international team studying the origins of SARS-CoV-2” (2021); [www.who.int/director-general/speeches/detail/who-director-general-s-remarks-at-the-member-state-briefing-on-the-report-of-the-international-team-studying-the-origins-of-sars-cov-2][18]. 6. [↵][19]US Department of State, “Joint statement on the WHO-Convened COVID-19 origins study” (2021); [www.state.gov/joint-statement-on-the-who-convened-covid-19-origins-study/][20]. 7. [↵][21]Delegation of the European Union to the UN and other International Organizations in Geneva “EU statement on the WHO-led COVID-19 origins study” (2021); . 8. [↵][22]1. J. Hollingsworth, 2. Y. Xiong , “The truthtellers: China created a story of the pandemic. These people revealed details Beijing left out,” CNN( 2021). 9. [↵][23]1. A. Green, 2. L. Wenliang , Lancet 395, 682 (2020). 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领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/326798
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Jesse D. Bloom,Yujia Alina Chan,Ralph S. Baric,et al. Investigate the origins of COVID-19[J]. Science,2021.
APA	Jesse D. Bloom.,Yujia Alina Chan.,Ralph S. Baric.,Pamela J. Bjorkman.,Sarah Cobey.,...&David A. Relman.(2021).Investigate the origins of COVID-19.Science.
MLA	Jesse D. Bloom,et al."Investigate the origins of COVID-19".Science (2021).