Dynamic remodeling of host membranes by self-organizing bacterial effectors

doi:10.1126/science.aay8118

GSTDTAP > 气候变化

DOI	10.1126/science.aay8118
	Dynamic remodeling of host membranes by self-organizing bacterial effectors
	Ting-Sung Hsieh; Victor A. Lopez; Miles H. Black; Adam Osinski; Krzysztof Pawłowski; Diana R. Tomchick; Jen Liou; Vincent S. Tagliabracci
	2021-05-28
发表期刊	Science
出版年	2021
英文摘要	Many pathogenic bacteria use molecular syringes to translocate proteins called effectors into the host cell to hijack the cellular machinery for their proliferation. Legionella pneumophila , the causative bacteria of Legionnaires' disease, uses a large effector arsenal and harnesses the host membrane system to establish a specialized vacuole where it replicates. Hsieh et al. show that, within this effector arsenal, the phospholipid kinase MavQ and the phosphatase SidP work together and self-organize on the intracellular membrane network of its eukaryotic host to promote membrane remodeling. The interactions between MavQ and SidP constitute positive and negative feedback loops, respectively, that orchestrate their spatiotemporal oscillation during infection. Science , aay8118, this issue p. [935][1] During infection, intracellular bacterial pathogens translocate a variety of effectors into host cells that modify host membrane trafficking for their benefit. We found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The Legionella effector MavQ, a phosphatidylinositol (PI) 3-kinase, was targeted to the endoplasmic reticulum (ER). MavQ and the Legionella PI 3-phosphatase SidP, even in the absence of other bacterial components, drove rapid PI 3-phosphate turnover on the ER and spontaneously formed traveling waves that spread along ER subdomains inducing vesicle and tubule budding. Thus, bacteria can exploit a self-organizing membrane-targeting mechanism to hijack host cellular structures for survival. [1]: /lookup/doi/10.1126/science.aay8118
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/328861
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ting-Sung Hsieh,Victor A. Lopez,Miles H. Black,et al. Dynamic remodeling of host membranes by self-organizing bacterial effectors[J]. Science,2021.
APA	Ting-Sung Hsieh.,Victor A. Lopez.,Miles H. Black.,Adam Osinski.,Krzysztof Pawłowski.,...&Vincent S. Tagliabracci.(2021).Dynamic remodeling of host membranes by self-organizing bacterial effectors.Science.
MLA	Ting-Sung Hsieh,et al."Dynamic remodeling of host membranes by self-organizing bacterial effectors".Science (2021).