Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain

doi:10.1126/science.abg8467

GSTDTAP > 气候变化

DOI	10.1126/science.abg8467
	Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain
	Ana C. Delgado; Angel R. Maldonado-Soto; Violeta Silva-Vargas; Dogukan Mizrak; Thomas von Känel; Kelly R. Tan; Alex Paul; Aviv Madar; Henar Cuervo; Jan Kitajewski; Chyuan-Sheng Lin; Fiona Doetsch
	2021-06-11
发表期刊	Science
出版年	2021
英文摘要	Neural stem cells in the adult mouse brain can generate both neurons and glia. Exactly where each stem cell is positioned can determine what type of neurons it generates. Delgado et al. show that neural stem cells are also choosy about what sorts of glia they make and when (see the Perspective by Baldwin and Silver). Injury or selective deletion of platelet-derived growth factor receptor β (PDGFRβ) from the stem cells kicked them into overdrive and revealed their selectivity with respect to gliogenesis. An unusual type of glial progenitor cell, intraventricular oligodendrocyte progenitors, are found nestled between the cilia of ependymal cells derived from tight clusters of PDGFRβ-expressing stem cells. Science , abg8467, this issue p. [1205][1]; see also abj1139, p. [1151][2] Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity. [1]: /lookup/doi/10.1126/science.abg8467 [2]: /lookup/doi/10.1126/science.abj1139
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/329915
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ana C. Delgado,Angel R. Maldonado-Soto,Violeta Silva-Vargas,et al. Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain[J]. Science,2021.
APA	Ana C. Delgado.,Angel R. Maldonado-Soto.,Violeta Silva-Vargas.,Dogukan Mizrak.,Thomas von Känel.,...&Fiona Doetsch.(2021).Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain.Science.
MLA	Ana C. Delgado,et al."Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain".Science (2021).