Strategies for durable β cell replacement in type 1 diabetes

doi:10.1126/science.abh1657

GSTDTAP > 气候变化

DOI	10.1126/science.abh1657
	Strategies for durable β cell replacement in type 1 diabetes
	Todd M. Brusko; Holger A. Russ; Cherie L. Stabler
	2021-07-30
发表期刊	Science
出版年	2021
英文摘要	Technological advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for people with type 1 diabetes. However, these efforts fall short of replicating the exquisite metabolic control provided by native islets. We examine the integrated advancements in islet cell replacement and immunomodulatory therapies that are coalescing to enable the restoration of endogenous glucose regulation. We highlight advances in stem cell biology and graft site design, which offer innovative sources of cellular material and improved engraftment. We also cover cutting-edge approaches for preventing allograft rejection and recurrent autoimmunity. These insights reflect a growing understanding of type 1 diabetes etiology, β cell biology, and biomaterial design, together highlighting therapeutic opportunities to durably replace the β cells destroyed in type 1 diabetes.
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/335508
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Todd M. Brusko,Holger A. Russ,Cherie L. Stabler. Strategies for durable β cell replacement in type 1 diabetes[J]. Science,2021.
APA	Todd M. Brusko,Holger A. Russ,&Cherie L. Stabler.(2021).Strategies for durable β cell replacement in type 1 diabetes.Science.
MLA	Todd M. Brusko,et al."Strategies for durable β cell replacement in type 1 diabetes".Science (2021).