SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

doi:10.1126/science.abi7994

GSTDTAP > 气候变化

DOI	10.1126/science.abi7994
	SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
	Matthew McCallum; Jessica Bassi; Anna De Marco; Alex Chen; Alexandra C. Walls; Julia Di Iulio; M. Alejandra Tortorici; Mary-Jane Navarro; Chiara Silacci-Fregni; Christian Saliba; Kaitlin R. Sprouse; Maria Agostini; Dora Pinto; Katja Culap; Siro Bianchi; Stefano Jaconi; Elisabetta Cameroni; John E. Bowen; Sasha W. Tilles; Matteo Samuele Pizzuto; Sonja Bernasconi Guastalla; Giovanni Bona; Alessandra Franzetti Pellanda; Christian Garzoni; Wesley C. Van Voorhis; Laura E. Rosen; Gyorgy Snell; Amalio Telenti; Herbert W. Virgin; Luca Piccoli; Davide Corti; David Veesler
	2021-08-06
发表期刊	Science
出版年	2021
英文摘要	As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern because they are resistant to antibodies elicited by infection or vaccination or they increase transmissibility or disease severity. Three papers used functional and structural studies to explore how mutations in the viral spike protein affect its ability to infect host cells and to evade host immunity. Gobeil et al. looked at a variant spike protein involved in transmission between minks and humans, as well as the B1.1.7 (alpha), B.1.351 (beta), and P1 (gamma) spike variants; Cai et al. focused on the alpha and beta variants; and McCallum et al. discuss the properties of the spike protein from the B1.1.427/B.1.429 (epsilon) variant. Together, these papers show a balance among mutations that enhance stability, those that increase binding to the human receptor ACE2, and those that confer resistance to neutralizing antibodies. Science , abi6226, abi9745, abi7994, this issue p. [641][1], p. [642][2], p. [648][3] A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate–based messenger RNA vaccine or from convalescent individuals exhibited neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies. [1]: /lookup/volpage/373/641?iss=6555 [2]: /lookup/doi/10.1126/science.abi9745 [3]: /lookup/doi/10.1126/science.abi7994
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/335574
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Matthew McCallum,Jessica Bassi,Anna De Marco,et al. SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern[J]. Science,2021.
APA	Matthew McCallum.,Jessica Bassi.,Anna De Marco.,Alex Chen.,Alexandra C. Walls.,...&David Veesler.(2021).SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.Science.
MLA	Matthew McCallum,et al."SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern".Science (2021).